Bonar M J, Hurtubise P E, Swerdlow S H
Diagn Clin Immunol. 1987;5(1):14-9.
T cells are known to be frequently numerous in follicular lymphomas but are generally considered to be a homogeneous population of small, round, "resting" lymphocytes. Although immunologic studies have suggested the presence of some "activated" T cells in these B-cell neoplasms, virtually no attention has been paid to the T-cell morphology. Wright-stained cytocentrifuged sheep erythrocyte (SRBC) rosette preparations from 20 cases of nodular follicular center cell lymphomas were therefore examined and the morphologic appearance of the SRBC rosetting cells was categorized. A mean of 19% (range 11-33%) of the SRBC-positive cells present were medium or large in size (diameter greater than two SRBCs, approximately 10 micron). A mean of 62% of SRBC-positive cells had round nuclei; 18% had indented nuclei and 20% had irregularly shaped nuclei. These data provide supportive morphologic evidence for some T-cell "activation" in certain follicular lymphomas. In addition to having possible functional and biologic implications, the previously undescribed presence of enlarged and sometimes "atypical" T cells in uncomplicated follicular lymphomas has implications for interpreting the histopathology of these B-cell neoplasms and the reported occurrence of composite T-cell/follicular center-cell lymphomas.
已知T细胞在滤泡性淋巴瘤中通常数量众多，但一般被认为是由小的、圆形的“静止”淋巴细胞组成的同质群体。尽管免疫学研究表明在这些B细胞肿瘤中存在一些“活化”的T细胞，但几乎没有人关注T细胞的形态。因此，对20例结节性滤泡中心细胞淋巴瘤的Wright染色细胞离心羊红细胞（SRBC）花环制备物进行了检查，并对SRBC花环形成细胞的形态外观进行了分类。所呈现的SRBC阳性细胞中，平均19%（范围为11%-33%）的细胞大小为中等或较大（直径大于两个SRBC，约10微米）。平均62%的SRBC阳性细胞具有圆形核；18%具有凹陷核，20%具有不规则形状的核。这些数据为某些滤泡性淋巴瘤中一些T细胞的“活化”提供了支持性的形态学证据。除了可能具有功能和生物学意义外，在单纯性滤泡性淋巴瘤中以前未描述过的增大的、有时“非典型”的T细胞的存在，对于解释这些B细胞肿瘤的组织病理学以及所报道的复合性T细胞/滤泡中心细胞淋巴瘤的发生情况具有重要意义。
