Drillenburg P, van der Voort R, Koopman G, Dragosics B, van Krieken J H, Kluin P, Meenan J, Lazarovits A I, Radaszkiewicz T, Pals S T
Department of Pathology, University of Amsterdam, The Netherlands.
Am J Pathol. 1997 Mar;150(3):919-27.
Recent studies have identified the integrin alpha 4 beta 7 as a mucosal homing receptor that mediates lymphocyte migration to the intestinal mucosa by binding to MAdCAM-1, a vascular recognition molecule (addressin) selectively expressed on mucosal endothelium. In the present study, we have assessed the expression of alpha 4 beta 7 on B- and T-cell non-Hodgkin's lymphomas of different primary localization and on related normal lymphocytes. Among B-lineage lymphomas, expression of alpha 4 beta 7 was present in the majority of cases of malignant lymphomatous polyposis of the intestine and low-grade lymphoma of the mucosa-associated lymphoid tissue/monocytoid B-cell lymphoma and in some cases of precursor B-cell lymphoma. CLL/small lymphocytic lymphoma, (nodal) mantle cell lymphoma, follicular center cell lymphoma, Burkitt's lymphoma, and diffuse large B-cell lymphoma were virtually always alpha 4 beta 7 negative, as was the case when localized in the mucosa-associated lymphoid tissue. The normal B cells of the follicle mantles and part of the B cells of the extrafollicular B-cell compartment of lymphoid tissues expressed moderate levels of alpha 4 beta 7. By contrast, follicular center cells were alpha 4 beta 7 negative. Among T-lineage lymphomas, expression of alpha 4 beta 7 was also strongly related to the primary localization; in mucosal, nodal, and cutaneous T cell lymphomas the percentage of positive cases was 56%, 17%, and 0%, respectively. All cases of precursor T-cell lymphoma were alpha 4 beta 7 negative. High expression of alpha 4 beta 7 was found on a subset of peripheral blood memory T cells as well as on lymphocytes in the intestinal mucosa. We conclude that non-Hodgkin's lymphomas that are related to mucosa-associated B- and T-lymphocyte populations selectively express the mucosal homing receptor alpha 4 beta 7. The presence of this receptor underscores their distinctive character and may play an important role in determining their characteristic mucosal dissemination pattern.
最近的研究已确定整合素α4β7是一种黏膜归巢受体，它通过与MAdCAM-1结合来介导淋巴细胞向肠黏膜迁移，MAdCAM-1是一种在黏膜内皮细胞上选择性表达的血管识别分子（地址素）。在本研究中，我们评估了α4β7在不同原发部位的B细胞和T细胞非霍奇金淋巴瘤以及相关正常淋巴细胞上的表达。在B细胞系淋巴瘤中，α4β7表达见于大多数肠道恶性淋巴瘤性息肉病、黏膜相关淋巴组织/单核细胞样B细胞淋巴瘤低度淋巴瘤病例以及部分前体B细胞淋巴瘤病例。慢性淋巴细胞白血病/小淋巴细胞淋巴瘤、（结节性）套细胞淋巴瘤、滤泡中心细胞淋巴瘤、伯基特淋巴瘤和弥漫性大B细胞淋巴瘤几乎总是α4β7阴性，当它们定位于黏膜相关淋巴组织时也是如此。淋巴组织滤泡套的正常B细胞和滤泡外B细胞区的部分B细胞表达中等水平的α4β7。相比之下，滤泡中心细胞α4β7阴性。在T细胞系淋巴瘤中，α4β7的表达也与原发部位密切相关；在黏膜、淋巴结和皮肤T细胞淋巴瘤中，阳性病例的百分比分别为56%、17%和0%。所有前体T细胞淋巴瘤病例均为α4β7阴性。在外周血记忆T细胞亚群以及肠黏膜淋巴细胞上发现α4β7高表达。我们得出结论，与黏膜相关B细胞和T细胞群体相关的非霍奇金淋巴瘤选择性表达黏膜归巢受体α4β7。该受体的存在突出了它们的独特特征，并可能在决定其特征性的黏膜播散模式中起重要作用。
