血清组织蛋白酶 L 与 2 型糖尿病患者外周动脉疾病相关。
Serum Legumain Is Associated with Peripheral Artery Disease in Patients with Type 2 Diabetes.
机构信息
Department of Endocrinology, Fujian Longyan First Hospital, Longyan First Affiliated Hospital of Fujian Medical University, Longyan 364000, China.
The Second School of Clinical Medicine, Southern Medical University, Guangzhou 510515, China.
出版信息
J Diabetes Res. 2021 Dec 18;2021:5651469. doi: 10.1155/2021/5651469. eCollection 2021.
BACKGROUND
Legumain is related to carotid atherosclerotic plaques and may be a new biomarker of carotid atherosclerosis. However, the association between legumain and peripheral artery disease (PAD) of lower extremity has been less studied. This study is aimed at exploring the potential link between legumain and PAD in patients with type 2 diabetes mellitus (T2DM).
METHODS
A cross-sectional study was conducted on 483 hospitalized T2DM patients. The serum legumain level was measured by a sandwich enzyme-linked immunosorbent assay. PAD was evaluated by color Doppler sonography. The association between legumain and PAD was tested by logistic regression. The predictive power of legumain for PAD was evaluated with the receiver-operating-characteristic (ROC) curve.
RESULTS
Overall, 201 (41.6%) patients suffered from PAD. Patients with PAD had significantly higher serum legumain level than those without PAD [11.9 (6.3, 17.9) g/L vs. 7.6 (3.2, 14.2) g/L, < 0.001]. Logistic regression showed that a higher serum legumain level was independently associated with a greater risk of PAD in T2DM patients [adjusted odds ratio (aOR): 1.03; 95% confidence interval (CI): 1.01-1.06]. The area under the ROC curve was 0.634 (95% CI, 0.585 to 0.684).
CONCLUSION
High serum legumain level was significantly correlated with an increased risk of PAD in T2DM patients.
背景
组织蛋白酶 L 与颈动脉粥样硬化斑块有关，可能是颈动脉粥样硬化的一个新的生物标志物。然而，组织蛋白酶 L 与下肢外周动脉疾病（PAD）的关系研究较少。本研究旨在探讨 2 型糖尿病（T2DM）患者中组织蛋白酶 L 与 PAD 之间的潜在联系。
方法
对 483 例住院 T2DM 患者进行横断面研究。采用夹心酶联免疫吸附试验测定血清组织蛋白酶 L 水平。采用彩色多普勒超声评估 PAD。采用 logistic 回归检验组织蛋白酶 L 与 PAD 的关系。采用受试者工作特征（ROC）曲线评估组织蛋白酶 L 对 PAD 的预测能力。
结果
共有 201 例（41.6%）患者患有 PAD。患有 PAD 的患者血清组织蛋白酶 L 水平明显高于未患有 PAD 的患者[11.9（6.3，17.9）μg/L 比 7.6（3.2，14.2）μg/L， < 0.001]。logistic 回归显示，较高的血清组织蛋白酶 L 水平与 T2DM 患者 PAD 风险增加独立相关[校正比值比（aOR）：1.03；95%置信区间（CI）：1.01-1.06]。ROC 曲线下面积为 0.634（95%CI，0.585 至 0.684）。
结论
血清组织蛋白酶 L 水平升高与 T2DM 患者 PAD 风险增加显著相关。
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