Centre of Public Health Sciences, University of Iceland, Reykjavík, Iceland.
Center for Research on Population Health, National Institute of Public Health, Mexico City, Mexico.
Stress. 2022 Jan;25(1):48-56. doi: 10.1080/10253890.2021.2011204. Epub 2022 Jan 10.
Women are exposed to a variety of life stressors, particularly violence, during their lifetime which increases the risk of developing various psychiatric and somatic diseases, with the dysregulated secretion of cortisol as one potential biological mechanism. We examined the association between violence and other life stressors and hair cortisol concentration (HCC) in a population of urban women. We included 470 adult women (age = 21-86 years) attending the Cancer Detection Clinic in Iceland. The Life Stressor Checklist-Revised (LSC-R; 30-items) was used to assess exposure. HCC was measured with liquid chromatography coupled with tandem mass spectrometry. We used linear regression models to assess the association between life stressors and log-transformed HCC. The median HCC (pg/mg) in the study population was 4.9 (range 0.6-616.6). HCC was not associated with background covariates, including age ( = 0.868), education level ( = 0.824), marital status ( = 0.545), income ( = 0.363), occupation ( = 0.192), but associated with current smoking ( = 0.013). We noted a 3.3% (95% CI: 0.17-6.6%) associated increase in HCC per endorsed life stressor after adjusting for age and smoking, while non-violent life stressors were not associated with HCC. Per endorsed violence item, we observed a 10.2% (95% CI: 1.4-19.7%) associated increase in HCC after age and smoking adjustment. Women with lifetime exposure to both physical and sexual violence presented with higher HCC than unexposed women ( = 0.010), after age and smoking adjustment. Lifetime exposure to violence was associated with higher levels of HCC in a community sample of women. These findings need confirmation with prospective studies.
女性在其一生中会面临各种生活压力源，尤其是暴力，这会增加她们患上各种精神和躯体疾病的风险，皮质醇分泌失调是其中一个潜在的生物学机制。我们在一个城市女性人群中研究了暴力和其他生活压力源与头发皮质醇浓度（HCC）之间的关系。我们纳入了 470 名成年女性（年龄 21-86 岁），她们都在冰岛的癌症检测诊所就诊。使用生活压力源检查表修订版（LSC-R；30 项）来评估暴露情况。通过液相色谱串联质谱法测量 HCC。我们使用线性回归模型来评估生活压力源与对数转换 HCC 之间的关联。研究人群的 HCC 中位数（pg/mg）为 4.9（范围 0.6-616.6）。HCC 与背景协变量无关，包括年龄（ = 0.868）、教育水平（ = 0.824）、婚姻状况（ = 0.545）、收入（ = 0.363）、职业（ = 0.192），但与当前吸烟有关（ = 0.013）。我们注意到，在调整年龄和吸烟因素后，每增加一个被认可的生活压力源，HCC 会相应增加 3.3%（95% CI：0.17-6.6%），而非暴力生活压力源与 HCC 无关。在调整年龄和吸烟因素后，每增加一个被认可的暴力事件，HCC 会相应增加 10.2%（95% CI：1.4-19.7%）。在调整年龄和吸烟因素后，与未暴露于暴力的女性相比，一生中同时经历过身体和性暴力的女性 HCC 水平更高（ = 0.010）。在社区女性样本中，一生中暴露于暴力与更高水平的 HCC 相关。这些发现需要前瞻性研究来证实。
