Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.
Division of Cardiac Surgery, Department of Surgery, University of Alberta, Edmonton, Alberta, Canada.
Clin Obes. 2022 Apr;12(2):e12506. doi: 10.1111/cob.12506. Epub 2021 Dec 28.
Obesity has been associated with increased incidence of comorbidities and shorter life expectancy, and it has generally been assumed that patients with obesity should have inferior outcomes after surgery. Previous literature has often demonstrated equivalent or even improved rates of mortality after cardiac surgery when compared to their lower-weight counterparts, coined the obesity paradox. Herein, we aim to review the literature investigating the impact of obesity on surgical valve interventions. PubMed and Embase were systematically searched for articles published from 1 January 2000 to 15 October 2021. A total of 1315 articles comparing differences in outcomes between patients of varying body mass index (BMI) undergoing valve interventions were reviewed and 25 were included in this study. Patients with higher BMI demonstrated equivalent or reduced rates of postoperative myocardial infarction, stroke, reoperation rates, acute kidney injury, dialysis and bleeding. Two studies identified increased rates of deep sternal wound infection in patients with higher BMI, although the majority of studies found no significant difference in deep sternal wound infection rates. The obesity paradox has described counterintuitive outcomes predominantly in coronary artery bypass grafting and transcatheter aortic valve replacement. Recent literature has identified similar trends in other heart valve interventions. While the obesity paradox has been well characterized, its causes are yet to be identified. Further study is essential in order to identify the causes of the obesity paradox so patients of all body sizes can receive optimal care.
肥胖与并发症发生率增加和预期寿命缩短有关,人们普遍认为肥胖患者在手术后的预后较差。以前的文献经常表明,与体重较低的患者相比,肥胖患者在心脏手术后的死亡率相当甚至更低,这被称为肥胖悖论。在此,我们旨在回顾评估肥胖对手术瓣膜干预影响的文献。系统地检索了 PubMed 和 Embase 数据库,以获取自 2000 年 1 月 1 日至 2021 年 10 月 15 日发表的文章。共回顾了 1315 篇比较不同体重指数(BMI)患者在接受瓣膜干预后结局差异的文章,其中 25 篇被纳入本研究。较高 BMI 的患者术后心肌梗死、中风、再次手术率、急性肾损伤、透析和出血的发生率相当或降低。有两项研究发现,较高 BMI 的患者深部胸骨伤口感染的发生率增加,但大多数研究发现深部胸骨伤口感染率没有显著差异。肥胖悖论主要描述了在冠状动脉旁路移植术和经导管主动脉瓣置换术中心律失常的反直觉结果。最近的文献也在其他心脏瓣膜介入治疗中发现了类似的趋势。虽然肥胖悖论已经得到了很好的描述,但它的原因尚未确定。进一步的研究对于确定肥胖悖论的原因至关重要,以便所有体型的患者都能得到最佳的治疗。