Kimby E, Mellstedt H, Nilsson B, Björkholm M, Holm G
Eur J Haematol. 1987 Mar;38(3):261-7. doi: 10.1111/j.1600-0609.1987.tb01174.x.
Total blood T lymphocytes and subpopulations (OKT4+ and OKT8+ cells) were studied in 59 patients with B cell chronic lymphocytic leukemia (B-CLL). In 48 previously untreated patients, total T lymphocytes were higher as compared to healthy controls (p less than 0.001). T-cells and OKT8+ cells were significantly increased in patients in advanced clinical stage and with progressive disease in comparison to patients with low stage and indolent disease. High numbers of OKT8+ lymphocytes were also seen in patients with a dominance of mu heavy chains on the leukemic clone. Moreover, in this patient group the OKT8+ subpopulation correlated with total B cells (r = 0.68, p less than 0.001) while in patients with a mu delta phenotype no such correlation was seen. After successful cytostatic therapy there was a reduction in total numbers of both OKT4+ and OKT8+ cells, in particular, with a concomitant increase in OKT4/OKT8 ratios.
对59例B细胞慢性淋巴细胞白血病（B-CLL）患者的全血T淋巴细胞及其亚群（OKT4+和OKT8+细胞）进行了研究。在48例未经治疗的患者中，全血T淋巴细胞数量高于健康对照组（p<0.001）。与低分期和惰性疾病患者相比，晚期临床分期和疾病进展患者的T细胞和OKT8+细胞显著增加。在白血病克隆上以μ重链为主的患者中也观察到大量OKT8+淋巴细胞。此外，在该患者组中，OKT8+亚群与总B细胞相关（r=0.68，p<0.001），而在具有μδ表型的患者中未观察到这种相关性。成功的细胞抑制治疗后，OKT4+和OKT8+细胞总数减少，尤其是OKT4/OKT8比值随之增加。
