Ghosh Abhishek, Kathiravan Sanjana, Sharma Kshitiz, Mattoo Surendra Kumar
Drug Deaddiction and Treatment Center, Department of Psychiatry, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Department of Psychiatry, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
J Sex Med. 2022 Feb;19(2):216-233. doi: 10.1016/j.jsxm.2021.11.018. Epub 2021 Dec 25.
Substance use may affect sexual functioning in both men and women. Comorbid sexual dysfunction adds to the clinical burden of substance use disorders (SUD).
The broad aims were to identify research conduct, types of the available evidence, and research gaps in (i) estimating the incidence, prevalence, type, and severity of sexual dysfunction in adults with SUD; (ii) exploring correlates of sexual dysfunction in SUD.
We conducted systematic searches on PubMed, Google Scholar, and Embase for studies published in the English language between August 1954 and November 2020. We included prospective and cross-sectional observational studies that had examined the prevalence or incidence of any sexual dysfunction in adults of either gender with substance use disorders. Review articles and those with an exclusive focus on tobacco use disorders were excluded. The review was registered in PROSPERO.
Our search identified 65 relevant articles, including five prospective studies. All the prospective studies and most of the cross-sectional studies (n = 40) were done among men and subjects with alcohol (n = 20) and opioid (n = 23) use disorders in clinical populations. Substance use and sexual dysfunction were assessed by a wide range of instruments. Prospective studies reported a prevalence of sexual dysfunction at 75% and 61% for alcohol and opioid use disorders, respectively. The prevalence of any sexual dysfunction in cross-sectional studies ranged between 15 and 100 percent. Erectile dysfunction was the most commonly studied and observed sexual dysfunction. Comorbidity and socioeconomic deprivation were consistently associated with a higher occurrence of sexual dysfunctions.
We did not limit our review by the type of substances and year of publication. We adhered to the standards of conducting and reporting scoping reviews; hence, our review results should be replicable, transparent, and reliable.
The wide clinical and methodological heterogeneity precluded a systematic review.
Research gaps exist in women, non-clinical population, stimulants, and cannabis use disorders, and effect of treatment of SUD in sexual functioning. The quality of evidence is poor. Ghosh A, Kathiravan S, Sharma K, Mattoo SK. A Scoping Review of the Prevalence and Correlates of Sexual Dysfunction in Adults With Substance use Disorders. J Sex Med 2022;19:216-233.
物质使用可能会影响男性和女性的性功能。合并存在的性功能障碍增加了物质使用障碍（SUD）的临床负担。
广泛的目的是确定在以下方面的研究开展情况、现有证据类型和研究空白：（i）估计患有SUD的成年人性功能障碍的发病率、患病率、类型和严重程度；（ii）探索SUD中性功能障碍的相关因素。
我们在PubMed、谷歌学术和Embase上进行了系统检索，以查找1954年8月至2020年11月间发表的英文研究。我们纳入了前瞻性和横断面观察性研究，这些研究调查了患有物质使用障碍的成年男女中任何性功能障碍的患病率或发病率。排除综述文章以及那些专门关注烟草使用障碍的文章。该综述已在国际前瞻性系统评价注册库（PROSPERO）登记。
我们的检索确定了65篇相关文章，包括5篇前瞻性研究。所有前瞻性研究以及大多数横断面研究（n = 40）都是在临床人群中的男性以及患有酒精（n = 20）和阿片类药物（n = 23）使用障碍的受试者中进行的。物质使用和性功能障碍通过多种工具进行评估。前瞻性研究报告酒精和阿片类药物使用障碍的性功能障碍患病率分别为75%和61%。横断面研究中任何性功能障碍的患病率在15%至100%之间。勃起功能障碍是研究和观察最频繁的性功能障碍。合并症和社会经济剥夺一直与性功能障碍的较高发生率相关。
我们没有按物质类型和发表年份限制我们的综述。我们遵循了开展和报告范围综述的标准；因此，我们的综述结果应具有可重复性、透明度和可靠性。
广泛的临床和方法学异质性排除了进行系统综述的可能性。
在女性、非临床人群、兴奋剂和大麻使用障碍以及SUD治疗对性功能的影响方面存在研究空白。证据质量较差。戈什A、卡蒂拉万S、夏尔马K、马图SK。对患有物质使用障碍的成年人性功能障碍患病率及相关因素的范围综述。《性医学杂志》2022；19：216 - 233。
