Larrey D, Amouyal G, Danan G, Degott C, Pessayre D, Benhamou J P
J Hepatol. 1987 Jun;4(3):327-9. doi: 10.1016/s0168-8278(87)80541-x.
We report the case of a patient in whom troleandomycin-induced hepatitis was followed by prolonged anicteric cholestasis. Jaundice occurred after administration of troleandomycin for 7 days and was associated with hypereosinophilia. Jaundice disappeared within 3 months but was followed by prolonged anicteric cholestasis marked by pruritus and high levels of alkaline phosphatase and gammaglutamyltransferase activities. Finally, pruritus disappeared within 19 months, and liver tests returned to normal 27 months after the onset of hepatitis. This observation demonstrates that prolonged cholestasis can follow troleandomycin-induced acute hepatitis.
我们报告了一例患者，其在服用醋竹桃霉素诱发肝炎后出现了长期的无黄疸型胆汁淤积。患者在服用醋竹桃霉素7天后出现黄疸，并伴有嗜酸性粒细胞增多。黄疸在3个月内消失，但随后出现了以瘙痒以及碱性磷酸酶和γ-谷氨酰转移酶活性升高为特征的长期无黄疸型胆汁淤积。最终，瘙痒在19个月内消失，肝脏检查在肝炎发作27个月后恢复正常。该观察结果表明，醋竹桃霉素诱发的急性肝炎后可出现长期胆汁淤积。
