Gan Da, Wang Xiaoyan, Xu Xiaochen, Kang Qingcong, Lu Zhonghua, Jia Menghan, Ru Yuan, He Xi, Mou Yun, He Wei, Zhu Shankuan
Chronic Disease Research Institute, The Children's Hospital, and National Clinical Research Center for Child Health, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Department of Nutrition and Food Hygiene, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Obesity (Silver Spring). 2022 Feb;30(2):482-490. doi: 10.1002/oby.23334. Epub 2021 Dec 28.
The present study aimed to investigate the associations of cholecystectomy with low muscle mass, low muscle strength, sarcopenia, and sarcopenic obesity.
This population-based study included data from 4,909 participants aged 18 to 80 years. History of cholecystectomy was diagnosed using abdominal ultrasonography. Muscle mass was evaluated using a dual-energy x-ray absorptiometry scan, and muscle strength was evaluated using an electronic hand dynamometer. Sarcopenia was defined as the presence of both low muscle mass and low muscle strength. Sarcopenic obesity was defined as the presence of both sarcopenia and obesity. Multivariable logistic regression models were performed to investigate the associations of cholecystectomy with low muscle mass, low muscle strength, sarcopenia, and sarcopenic obesity.
Participants with history of cholecystectomy were more likely than those without to have low muscle mass, low muscle strength, and sarcopenia. Furthermore, compared with cholecystectomy that occurred within 7 years (7 years is the median interval between cholecystectomy and the physical examination), participants with cholecystectomy that occurred more than 7 years ago had higher odds of sarcopenia. Finally, whether obesity was defined by BMI or body fat percentage, cholecystectomy was positively associated with sarcopenic obesity.
Cholecystectomy is associated with low muscle mass, low muscle strength, sarcopenia, and sarcopenic obesity.
本研究旨在调查胆囊切除术与低肌肉量、低肌肉力量、肌少症和肌少症肥胖之间的关联。
这项基于人群的研究纳入了4909名年龄在18至80岁之间参与者的数据。通过腹部超声诊断胆囊切除术史。使用双能X线吸收法扫描评估肌肉量，使用电子握力计评估肌肉力量。肌少症定义为同时存在低肌肉量和低肌肉力量。肌少症肥胖定义为同时存在肌少症和肥胖。采用多变量逻辑回归模型来研究胆囊切除术与低肌肉量、低肌肉力量、肌少症和肌少症肥胖之间的关联。
有胆囊切除术史的参与者比没有该病史的参与者更有可能出现低肌肉量、低肌肉力量和肌少症。此外，与7年内进行胆囊切除术的参与者（7年是胆囊切除术与体格检查之间的中位间隔时间）相比，7年以上进行胆囊切除术的参与者患肌少症的几率更高。最后，无论肥胖是通过BMI还是体脂百分比来定义，胆囊切除术都与肌少症肥胖呈正相关。
胆囊切除术与低肌肉量、低肌肉力量、肌少症和肌少症肥胖有关。
