Department of Pathology, Peking University People's Hospital, Beijing, China.
Histol Histopathol. 2022 Feb;37(2):181-188. doi: 10.14670/HH-18-417. Epub 2021 Dec 29.
To study diagnosis, differential diagnosis, and origin of easily misdiagnosed adult gastric duplication cysts.
Six cases with GDCs were studied using immunohistochemical methods to research the expression of tumor markers.
Most GDCs were located in the abdominal cavity outside the digestive organs. The cyst wall tissues included a repetition of the full-thickness structure of the stomach wall that was lined by a variety of different epithelia. The expression of CK7 was positive in all epithelia (6/6), while CK7 expression was positive in cardia glands in 5/5 and positive in fundus glands in 1/5. CK 20 was 100% (4/4) positively expressed in the SCE, 100% (3/3) negative in the CCE, and in the SE. It was also expressed positively 100% (5/5) in fundus glands and 80% (4/5) in cardia glands. Both CK7 and CK20 were negatively expressed in the pyloric glands in case 3. The expression of MUC1 was positive in all epithelia and glands, whereas MUC2 expression was negative. MUC5AC was expressed differently in epithelia and glands.
GDCs can originate from the antrum or the fundus of the stomach. Tumor markers can help diagnosis and differential diagnosis. This study may help to improve clinical precision treatment.
研究易误诊的成人胃重复囊肿的诊断、鉴别诊断和来源。
使用免疫组织化学方法研究 6 例 GDC 中肿瘤标志物的表达。
大多数 GDC 位于消化道外的腹腔内。囊壁组织包括胃壁全层结构的重复，由各种不同的上皮组成。所有上皮（6/6）均表达 CK7，5/5 的贲门腺阳性，1/5 的底体腺阳性。SCE 中 CK20 阳性率为 100%（4/4），CCE 和 SE 均为 100%（3/3）阴性，底体腺阳性率为 100%（5/5），贲门腺阳性率为 80%（4/5）。第 3 例中 CK7 和 CK20 均在幽门腺中阴性表达。所有上皮和腺体均表达 MUC1，而 MUC2 表达阴性。MUC5AC 在不同的上皮和腺体中有不同的表达。
GDC 可起源于胃窦或胃底。肿瘤标志物有助于诊断和鉴别诊断。本研究有助于提高临床精准治疗水平。
