人表皮生长因子受体2在乳腺外佩吉特病和乳腺佩吉特病中的表达。 - Suppr | 超能文献

Human epidermal growth factor receptor 2 expression in extramammary Paget's disease and mammary Paget's disease.

作者信息

Jeong Soo Hyun, Hyeong Jin Hyeok, Park Eun Joo, Kim Kwang Joong, Kim Kwang Ho

机构信息

Department of Dermatology, College of Medicine, Hallym University, Anyang, Korea.

出版信息

Australas J Dermatol. 2022 Feb;63(1):115-118. doi: 10.1111/ajd.13782. Epub 2021 Dec 29.

DOI:10.1111/ajd.13782

Abstract

摘要

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Human epidermal growth factor receptor 2 expression in extramammary Paget's disease and mammary Paget's disease.人表皮生长因子受体2在乳腺外佩吉特病和乳腺佩吉特病中的表达。

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Intraepidermal cytokeratin 7 expression is not restricted to Paget cells but is also seen in Toker cells and Merkel cells.表皮内细胞角蛋白7的表达并不局限于佩吉特细胞，在托克尔细胞和默克尔细胞中也可见到。

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Reduced E-cadherin expression correlates with disease progression in Paget's disease of the vulva but not Paget's disease of the breast.E-钙黏蛋白表达降低与外阴佩吉特病的疾病进展相关，但与乳腺佩吉特病无关。

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Assessment of HER2 status in extramammary Paget disease and its implication for disitamab vedotin, a novel humanized anti-HER2 antibody-drug conjugate therapy.乳腺外佩吉特病中HER2状态的评估及其对新型人源化抗HER2抗体-药物偶联物疗法迪西他单抗维莫非尼的意义。

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