Bertholet Nicolas, Marmet Simon, Wicki Matthias, Gmel Gerhard, Studer Joseph
Addiction Medicine, Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Switzerland.
Swiss Med Wkly. 2021 Dec 20;151:w30054. doi: 10.4414/smw.2021.w30054.
In Switzerland, there has been a boom in the market for cannabidiol (CBD) products in recent years. However, little is known on the prevalence, modes of administration and motives for use of CBD products. The aim of the present study was to fill this gap using recent (2019) data from the Cohort Study on Substance Use Risk Factors (C-SURF).
Between April and December 2019, an unselected sample of 5233 Swiss young men from the French- and German-speaking regions (mean age 28.2 years, standard deviation 1.3) completed a self-report questionnaire covering measures of use of CBD products, modes of administration and motives to use of CBD, tetrahydrocannabinol (THC) and cigarettes. Descriptive statistics were used to estimate prevalence of self-reported use, modes of administration and motives to use CBD, whereas logistic regression models were used to test the associations of linguistic region, THC and tobacco use with use of CBD.
Lifetime and 12-month prevalence of self-reported use of CBD were 32.4% and 18.5%, respectively. Among past 12-month CBD users, 79.4% used CBD once a month or less often, whereas 20.6% used it more than once a month. The most often reported modes of administration of CBD were in association with tobacco: flowers mixed with tobacco (67.5%), and CBD cigarettes with tobacco (37.1%), while 18.6% used flowers without tobacco. The three most reported reasons for using CBD were: out of curiosity (74.0%), to feel the effects of THC (38.1%) and for well-being and health (37.5%). In multivariable models, CBD use was associated with use of THC (odds ratio [OR] 9.85, 95% confidence interval [CI] 8.28-11.73), cigarettes (OR 2.74, 95% CI 2.28-3.29) or e-cigarettes (OR 1.5795% CI 1.27-1.95), as well as for the linguistic region (French-speaking vs German-speaking region OR 1.3895% CI 1.15-1.65).
Self-reported use of CBD is common among young Swiss men: about one third used CBD in their life and about one in five in the previous 12 months. However, the vast majority of CBD users used it infrequently and out of curiosity. CBD use was particularly prevalent among users of THC and cigarette smokers. CBD was most often used in combination with tobacco, thus exposing users to risks associated with smoking tobacco products.
近年来，瑞士大麻二酚（CBD）产品市场蓬勃发展。然而，关于CBD产品的使用 prevalence、给药方式和使用动机，人们了解甚少。本研究的目的是利用物质使用风险因素队列研究（C-SURF）的最新（2019年）数据填补这一空白。
2019年4月至12月期间，从瑞士法语区和德语区未经过挑选的5233名年轻男性样本（平均年龄28.2岁，标准差1.3）完成了一份自我报告问卷，内容包括CBD产品使用情况、给药方式以及使用CBD、四氢大麻酚（THC）和香烟的动机。描述性统计用于估计自我报告的CBD使用 prevalence、给药方式和使用动机，而逻辑回归模型用于检验语言区域、THC和烟草使用与CBD使用之间的关联。
自我报告的CBD终身使用 prevalence和12个月使用 prevalence分别为32.4%和18.5%。在过去12个月的CBD使用者中，79.4%每月使用CBD一次或更少，而20.6%每月使用超过一次。最常报告的CBD给药方式与烟草有关：花与烟草混合（67.5%），含烟草的CBD香烟（37.1%），而18.6%使用不含烟草的花。报告的使用CBD的三个最主要原因是：出于好奇（74.0%），感受THC的效果（38.1%）以及为了身心健康（37.5%）。在多变量模型中，CBD使用与THC使用（优势比[OR]9.85，95%置信区间[CI]8.28 - 11.73）、香烟（OR 2.74，95%CI 2.28 - 3.29）或电子烟（OR 1.57，95%CI 1.27 - 1.95）以及语言区域（法语区与德语区相比，OR 1.38，95%CI 1.15 - 1.65）相关。
自我报告的CBD使用在瑞士年轻男性中很常见：约三分之一的人一生中有过CBD使用经历，约五分之一的人在过去12个月内使用过。然而，绝大多数CBD使用者使用频率低且出于好奇。CBD使用在THC使用者和吸烟者中尤为普遍。CBD最常与烟草联合使用，从而使使用者面临与吸食烟草产品相关的风险。
