Institute of Materials and Environmental Chemistry, Research Centre for Natural Sciences, Eötvös Loránd Research Network, Magyar tudósok körútja 2, Budapest, 1117, Hungary.
Department of Pharmacognosy, Faculty of Pharmacy, University of Szeged, Eötvös u. 6, Szeged, 6720, Hungary.
Sci Rep. 2021 Apr 26;11(1):8951. doi: 10.1038/s41598-021-88389-z.
The use of cannabidiol (CBD) in electronic cigarettes is widespread. Previously, it was reported that CBD is partly transformed to THC in case smoking as a cigarette, however, the pyrolysis of this compound has not been assessed extensively. The aim of our study was to investigate the effect of temperature on the composition of pyrolysis products of CBD. The experiments were performed in the typical operating temperature range of e-cigarettes (250-400 °C) and at 500 °C under both inert and oxidative conditions, and the pyrolysis products were identified and quantified by GC-MS. Depending on the temperature and atmosphere, 25-52% of CBD was transformed into other chemical substances: Δ-THC, Δ-THC, cannabinol and cannabichromene were the predominant pyrolysates in both conditions, all formed by cyclization reaction. THC was the main pyrolysis product at all temperatures under both oxidative and inert conditions. Our results point out that CBD in e-cigarettes can be considered as a precursor of THC, thus it bears all the dangers related to this psychoactive compound. Our findings are fundamental contributions to the safety profile of CBD-based e-cigarettes.
电子烟中广泛使用大麻二酚 (CBD)。此前有报道称，CBD 在作为香烟吸烟时会部分转化为 THC，但该化合物的热解尚未得到广泛评估。我们的研究旨在调查温度对 CBD 热解产物组成的影响。实验在电子烟的典型工作温度范围内（250-400°C）和惰性和氧化条件下的 500°C 下进行，并通过 GC-MS 鉴定和定量分析热解产物。根据温度和气氛的不同，25-52%的 CBD 转化为其他化学物质：Δ-THC、Δ-THC、大麻醇和大麻色烯是两种条件下的主要热解产物，均通过环化反应形成，THC 是两种条件下所有温度下的主要热解产物。我们的结果表明，电子烟中的 CBD 可以被视为 THC 的前体，因此它具有与这种精神活性化合物相关的所有危险。我们的发现是对基于 CBD 的电子烟安全状况的重要贡献。
