晚期癌症患者下颌运动与呼吸的流行病学：一项多中心前瞻性队列研究。
Epidemiology of Respiration with Mandibular Movement in Advanced Cancer Patients: A Multicenter Prospective Cohort Study.
机构信息
Department of Palliative Care Unit, JCHO Tokyo Shinjuku Medical Center, Tokyo, Japan.
Palliative and Supportive Care Division, Seirei Mikatahara Hospital, Hamamatsu, Japan.
出版信息
J Palliat Med. 2022 Mar;25(3):461-464. doi: 10.1089/jpm.2021.0328. Epub 2021 Dec 29.
Respiration with mandibular movement (RMM) is one of the important clinical signs of impending death. However, there is very limited data on its natural course. This study was conducted in 23 inpatient palliative care units in Japan. It aimed to explore the natural course of RMM. Among a total of 1526 cancer patients included, 1065 patients (69.8%) had RMM. A total of 14.8% patients experienced respiratory arrest within 30 minutes from RMM onset, 14.3% within 30-60 minutes, 34.4% within 1-4 hours, 17.5% within 4-12 hours, 8.9% within 12-24 hours, and 10.4%> 24 hours. Mean oxygen saturation and percentage of patients with SpO ≥90% at RMM onset were found to be significantly higher in patients with longer durations from RMM onset to death ( < 0.001). RMM occurred in a majority (80%) of dying patients within 12 hours. A minority of the patients survived >24 hours.
下颌运动性呼吸（RMM）是临终前的重要临床征象之一。然而，关于其自然病程的数据非常有限。本研究在日本的 23 家姑息治疗住院病房进行，旨在探讨 RMM 的自然病程。在总共纳入的 1526 例癌症患者中，有 1065 例（69.8%）存在 RMM。从 RMM 发作到呼吸停止的时间在 30 分钟内的患者有 14.8%，在 30-60 分钟内的有 14.3%，在 1-4 小时内的有 34.4%，在 4-12 小时内的有 17.5%，在 12-24 小时内的有 8.9%，>24 小时的有 10.4%。RMM 发作到死亡的时间越长，患者的平均氧饱和度和 SpO≥90%的患者比例越高（ < 0.001）。在 12 小时内，大多数（80%）临终患者出现 RMM。少数患者存活时间>24 小时。
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