Shigemoto M, Yokoyama I, Shibuya M
Gan No Rinsho. 1987 Apr;33(5 Suppl):522-6.
Cell-mediated immunity of the aging and immune response in the family of gastric cancer have been investigated and the following results were obtained. Immune response particularly of cell-mediated immunity was found decreased in paralled with aging; decreases in peripheral lymphocyte and T-cell counts, rate of Con A and PHA induced blastoid transformation, and the tendency of increase in suppressor T-cell were noted. Investigations on the immune response in the family of gastric cancer revealed that cell-mediated immune response was recreased in the compared to age-matched healthy volunteers. These findings suggest that latent immunological failure may exist in the above family.
对老年细胞介导免疫以及胃癌家族中的免疫反应进行了研究，获得了以下结果。发现免疫反应，尤其是细胞介导免疫反应，随着衰老而下降；外周淋巴细胞和T细胞计数减少，伴刀豆球蛋白A和植物血凝素诱导的母细胞转化速率下降，且抑制性T细胞有增加趋势。对胃癌家族中免疫反应的研究表明，与年龄匹配的健康志愿者相比，细胞介导免疫反应降低。这些发现提示上述家族中可能存在潜在的免疫功能衰竭。
