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Snakebite Envenomation and Endocrine Dysfunction蛇咬伤中毒与内分泌功能障碍
2
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蛇咬伤中毒与内分泌功能障碍

Snakebite Envenomation and Endocrine Dysfunction

作者信息

Bhattacharya Saptarshi, Nagendra Lakshmi, Tyagi Priyamvada

机构信息

Senior Consultant, Department of Endocrinology, Indraprastha Apollo Hospitals, Sarita Vihar, Delhi, India, 110076

Assistant Professor, Department of Endocrinology, K.S Hegde Medical Academy, Mangalore, India, 575018

PMID:34965059
Abstract

Snakebite envenoming (SBE) is a life-threatening medical emergency encountered in tropical parts of Asia, Africa, and Latin America. Toxins in the venom cause local damage and multi-organ dysfunction, predominantly affecting neurological, hematological, and vascular systems. Endocrine anomalies are less frequently reported and often masked by more severe disorders. Anterior pituitary insufficiency is the most common endocrine manifestation and mainly observed after Russell’s viper ( and ) bite. SBE-induced hypopituitarism can manifest early or have a delayed presentation. Primary adrenal insufficiency, hyponatremia, hypokalemia, hyperkalemia, and hyperglycemia are also described. These complications are uncommon and under-reported, as SBE occurs in remote areas and medical facilities for endocrine assessment might not be available. Timely identification and management of these problems are critical for optimum medical outcome. For complete coverage of all related areas of Endocrinology, please visit our on-line FREE web-text, WWW.ENDOTEXT.ORG.

摘要

蛇咬伤中毒(SBE)是亚洲、非洲和拉丁美洲热带地区遇到的一种危及生命的医疗急症。毒液中的毒素会造成局部损伤和多器官功能障碍,主要影响神经、血液和血管系统。内分泌异常的报告较少,且常被更严重的疾病所掩盖。垂体前叶功能减退是最常见的内分泌表现,主要在被罗素蝰蛇(及)咬伤后观察到。SBE引起的垂体功能减退可早期出现或延迟表现。原发性肾上腺功能不全、低钠血症、低钾血症、高钾血症和高血糖也有报道。这些并发症并不常见且报告不足,因为SBE发生在偏远地区,可能没有进行内分泌评估的医疗设施。及时识别和处理这些问题对于获得最佳医疗结果至关重要。如需全面涵盖内分泌学的所有相关领域,请访问我们的在线免费网络文本,WWW.ENDOTEXT.ORG。