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罗素蝰蛇咬伤可导致腹直肌鞘血肿。

Russell's viper envenomation induces rectus sheath haematoma.

作者信息

Senthilkumaran Subramanian, Almeida José R, Williams Jarred, Salim Anika, Williams Harry F, Thirumalaikolundusubramanian Ponniah, Patel Ketan, Vaiyapuri Sakthivel

机构信息

Manian Medical Centre, Erode, 638001, Tamil Nadu, India.

School of Pharmacy, University of Reading, Reading, RG6 6UB, UK.

出版信息

Toxicon. 2023 Mar 1;224:107037. doi: 10.1016/j.toxicon.2023.107037. Epub 2023 Jan 21.

Abstract

Snakebite envenomation causes systemic and local manifestations, which result from the individual or synergistic actions of multiple venom components. The pathological hallmarks of medically important venomous snakes such as the Indian Russell's viper (Daboia russelii) are well known. Envenomation by Russell's viper is typically characterised by coagulopathies, muscular damage, nephrotoxicity, and neurotoxicity. However, recent reports have revealed several unusual complications that provide a better understanding of Russell's viper envenomation effects. To further strengthen this, here, we report a case of Russell's viper bite that induced acute abdominal pain, which was intensified on day two and conservatively treated under medical supervision. Both Fothergill and Carnett signs were positive for this patient. An ultrasound imaging revealed a dissimilar dense mass, and the abdominal computed tomography scan confirmed rectus sheath haematoma. The clinical management involved the administration of polyvalent antivenom, packed red blood cells, fresh frozen plasma, and platelets. The patient recovered gradually and was discharged from the hospital eight days after the bite. Overall, this case presentation shares an uncommon experience and adds new insights into the complex series of rare pathological events associated with Russell's viper bites in India. The scientific documentation of relatively infrequent entities based on an ongoing living assessment of medical experiences, for example, this rectus sheath haematoma, constitutes valuable guidance for an adequate diagnosis and timely treatment. Essential awareness among clinicians and further research on understanding the molecular relationship between Russell's viper venom and rectus sheath haematoma will improve patient outcomes and understanding of this condition, respectively.

摘要

蛇咬伤中毒会导致全身和局部表现,这是多种毒液成分单独作用或协同作用的结果。印度锯鳞蝰(Daboia russelii)等具有医学重要性的毒蛇的病理特征是众所周知的。锯鳞蝰咬伤中毒的典型特征是凝血功能障碍、肌肉损伤、肾毒性和神经毒性。然而,最近的报告揭示了一些不寻常的并发症,这有助于更好地理解锯鳞蝰咬伤中毒的影响。为了进一步强化这一点,我们在此报告一例锯鳞蝰咬伤导致急性腹痛的病例,该腹痛在第二天加剧,并在医学监护下进行了保守治疗。该患者的福瑟吉尔征和卡内特征均为阳性。超声成像显示有一个不同的致密肿块,腹部计算机断层扫描证实为腹直肌鞘血肿。临床治疗包括给予多价抗蛇毒血清、浓缩红细胞、新鲜冰冻血浆和血小板。患者逐渐康复,咬伤八天后出院。总体而言,该病例报告分享了一种不常见的经历,并为印度与锯鳞蝰咬伤相关的一系列复杂罕见病理事件增添了新的见解。基于对医疗经验的持续实时评估,对相对罕见的病症进行科学记录,例如本病例中的腹直肌鞘血肿,可为准确诊断和及时治疗提供有价值的指导。临床医生的基本认识以及对锯鳞蝰毒液与腹直肌鞘血肿之间分子关系的进一步研究,将分别改善患者的治疗效果并增进对这种病症的理解。

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