School of Medicine, Royal College of Surgeons in Ireland - Medical University of Bahrain, Muharraq, Bahrain.
Dermatology. 2022;238(4):807-810. doi: 10.1159/000520298. Epub 2021 Dec 29.
Acneiform eruption is a devastating cutaneous side effect of cetuximab, a monoclonal antibody used to treat a variety of cancers. Despite its effectiveness, many patients avoid or discontinue it after experiencing its dermatological side effects as it negatively impacts their quality of life (QoL). This displays the immense need for multidisciplinary collaboration to prevent and treat cetuximab-induced acneiform eruption (CIAE). Prevention methods include, but are not limited to, education, skin care routines, and prophylactic drugs. The following measures reduce the likelihood of developing CIAE and decrease its severity, making it easier to treat if it were to occur. Ongoing research on the treatment of CIAE continues. Of these treatments, oral tetracyclines and systemic corticosteroids have been shown to be the most effective by far. This commentary aims to evaluate the study by Park et al. [Dermatology. 2021;237(3):457-63], further elaborate on prevention and treatment measures of CIAE, and highlight the implications of CIAE on a patient's QoL.
痤疮样疹是西妥昔单抗（一种用于治疗多种癌症的单克隆抗体）的一种严重皮肤副作用。尽管它很有效，但许多患者在经历其皮肤病副作用后会避免或停止使用它，因为它会对他们的生活质量（QoL）产生负面影响。这表明需要多学科合作来预防和治疗西妥昔单抗诱导的痤疮样疹（CIAE）。预防方法包括但不限于教育、皮肤护理常规和预防性药物。以下措施降低了发生 CIAE 的可能性，并降低了其严重程度，如果发生 CIAE，治疗也会变得更容易。目前正在继续进行 CIAE 的治疗研究。在这些治疗方法中，口服四环素类药物和全身皮质类固醇类药物迄今为止被证明是最有效的。本文旨在评价 Park 等人的研究[Dermatology. 2021;237(3):457-63]，进一步阐述 CIAE 的预防和治疗措施，并强调 CIAE 对患者 QoL 的影响。
