State Institution «National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine», 53 Yuriia Illienka Str., Kyiv, 04050, Ukraine.
Scientific Coordination Department of the National Academy of Medical Sciences of Ukraine, 12 Herzen Str., Kyiv, 04050, Ukraine.
Probl Radiac Med Radiobiol. 2021 Dec;26:284-296. doi: 10.33145/2304-8336-2021-26-284-296.
One of the current problems of modern radiobiology is determine the characteristics of the manifestation of radiation-induced effects not only at different dose loads, but also at different stages of development of the organism. In previous reports, we have summarized available evidence that at certain ages there is a comparative acceleration of radiation-induced pathological changes in the eye and brain, and the study and assessment of the risk of possible ophthalmic and neurological pathology in remote periods after contamination of radioactive areas. Data of irradiated in utero individuals are possible on the basis of observation of the state of the visual analyzer in persons who underwent intrauterine irradiation in 1986. Therefore, a parallel study of retinal morphometric parameters, amplitude and latency of components of evoked visual potentials in irradiated in utero individuals was performed.
to evaluate the retinal morphometric parameters, amplitude and latency components of the evoked visual potentials in intrauterine irradiated persons.
The results of surveys of 16 people irradiated in utero in the aftermath of the Chornobyl disaster were used; the comparison group were residents of Kyiv of the corresponding age (25 people). Optical coherence tomography was performed on a Cirrus HD-OCT, Macular Cube 512x128 study technique was used. At the same time, the study of visual evoked potentials on the inverted pattern was performed, and occipital leads wereanalyzed. Visual evoked potentials were recorded on a reversible chess pattern (VEP) - an electrophysiological test, which is a visual response to a sharp change in image contrast when presenting a reversible image of a chessboard.
In those irradiated in utero at the age of 22-25 years, there was a probable increase in retinal thickness in the fovea, there was a tendency to increase the thickness of the retina in the areas around the fovea. When recording visual evoked potentials on a reversible chess pattern in this group, there was a tendency to decrease the amplitudes of components (N75, P100, N145, P200) in the right and left parieto-occipital areas and asymmetric changes in latency of these components.
Early changes of fovea recorded in OCT and decreasing amplitudes of components of visual evoked potentials on the reversible chess pattern at the age of 22 25 years may indicate a risk of development in patients irradiated in utero, early age-related macular degeneration, as well as increased risk and increased risk structures of the visual analyzer.
现代放射生物学的当前问题之一是确定不仅在不同剂量负荷下，而且在机体发育的不同阶段，辐射诱导效应表现的特征。在以前的报告中，我们总结了现有证据，即在某些年龄，眼睛和大脑中的辐射诱导性病变会加速发展，并且在放射性区域受到污染后的远程时期，对可能的眼部和神经病理学的风险进行研究和评估。可以根据 1986 年宫内照射个体的视觉分析器状态的观察，获得对宫内照射个体的放射性照射数据。因此，对宫内照射个体的视网膜形态参数、诱发视觉诱发电位的幅度和潜伏期进行了平行研究。
评估宫内照射个体的视网膜形态参数、诱发视觉诱发电位的幅度和潜伏期成分。
利用了 16 名在切尔诺贝利灾难后宫内受照射者的调查结果；对照组为基辅的相应年龄的居民（25 人）。使用 Cirrus HD-OCT 进行光学相干断层扫描，使用黄斑 Cube 512x128 研究技术。同时，进行倒置模式的视觉诱发电位研究，并对枕叶导联进行分析。在可逆棋盘上记录视觉诱发电位（VEP）-这是一种电生理测试，它是在呈现棋盘的可逆图像时，对图像对比度的急剧变化的视觉反应。
在 22-25 岁宫内受照射的个体中，黄斑区视网膜厚度可能增加，黄斑周围区域视网膜厚度有增加的趋势。在该组中，在可逆棋盘上记录视觉诱发电位时，右侧和左侧顶枕叶区域的各成分（N75、P100、N145、P200）的幅度有降低的趋势，并且这些成分的潜伏期出现不对称变化。
在 22-25 岁时在 OCT 中记录到的黄斑早期变化，以及在可逆棋盘上记录到的视觉诱发电位各成分的幅度降低，可能表明宫内受照射的患者有发展的风险，早期年龄相关性黄斑变性，以及增加的风险和增加的视觉分析器结构的风险。
