Fedirko P, Babenko T, Kolosynska O, Dorichevska R, Garkava N, Grek L, Vasylenko V, Masiuk S
State Institution «National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine», 53 Melnykova str., Kyiv, 04050, Ukraine.
State Institution «Dnipropetrovsk Medical Academy of the Ministry of health of Ukraine», Vernadsky str, 9, Dnipro, 49044, Ukraine.
Probl Radiac Med Radiobiol. 2018 Dec;23:481-489. doi: 10.33145/2304-8336-2018-23-481-489.
evaluate the retinal morphometric parameters of the reconvalescents in remote period after acute radi-ation sickness.
A complete ophthalmologic examination was carried out on 7 reconvalescents of acuteradiation sickness. The examined are divided into two subgroups: 1) patients with macular degeneration of the reti-na (8 eyes); 2) patients without clinical signs of macular pathology (6 eyes). Parameters of the retina in the cen-tral retina zone studied using the method of optical coherence tomography. To evaluate the results of surveys usedstatistical methods: average values of quantitative indicators calculation, estimation of probability difference byStudent's method.
Optical coherence tomography revealed a statistically significant increase of the thickness of the retina inthe fovea in all reconvalescents of acute radiation sickness.
It was shown that the thickness of the retina in the fovea and paramacular zone in persons who suf-fered acute radiation sickness is significantly higher than in the control. These changes observed in all reconvalis-cents ARS - both in person with sings of macular degeneration, and in those whose clinical manifestations were notdetected. The presence of a correlation between the volume of the retina in the macular zone and the documentedradiation dose of the study group emphasizes the perspectives of next OCT examination of the retina of reconvales-cents of ARS to study the mechanism of retina's damage in this category of victims of the Chornobyl accident.
评估急性放射病恢复期患者远期视网膜形态学参数。
对7例急性放射病恢复期患者进行了全面的眼科检查。受检者分为两个亚组：1）视网膜黄斑变性患者（8只眼）；2）无黄斑病变临床体征的患者（6只眼）。采用光学相干断层扫描方法研究中央视网膜区域的视网膜参数。使用统计方法评估调查结果：计算定量指标的平均值，用学生氏法估计概率差异。
光学相干断层扫描显示，急性放射病所有恢复期患者的黄斑中心凹视网膜厚度均有统计学意义的增加。
结果表明，急性放射病患者的黄斑中心凹和黄斑旁区域的视网膜厚度显著高于对照组。在急性放射病所有恢复期患者中均观察到这些变化——无论是有黄斑变性体征的患者，还是未检测到临床表现的患者。黄斑区视网膜体积与研究组记录的辐射剂量之间存在相关性，这强调了对急性放射病恢复期患者进行下一步视网膜光学相干断层扫描检查以研究此类切尔诺贝利事故受害者视网膜损伤机制的前景。
