Institute and Outpatient Clinic for Occupational and Social Medicine, Justus-Liebig-University, Aulweg 129, 35392, Giessen, Germany.
Institute of Inorganic and Analytical Chemistry, Justus-Liebig-University, Heinrich-Buff-Ring 17, 35392, Giessen, Germany.
Part Fibre Toxicol. 2021 Dec 29;18(1):48. doi: 10.1186/s12989-021-00441-y.
Refractory Ceramic fibres (RCF) are man-made mineral fibres used in high performance thermal insulation applications. Analogous to asbestos fibres, RCF are respirable, show a pleural drift and can persist in human lung tissue for more than 20 years after exposure. Pleural changes such as localised or diffuse pleural thickening as well as pleural calcification were reported.
A 45 years old man worked in high performance thermal insulation applications using refractory ceramic fibres (RCF) for almost 20 years. During a occupational medical prophylaxis to ensure early diagnosis of disorders caused by inhalation of aluminium silicate fibres with X-ray including high-resolution computed tomography (HRCT), bilateral pleural thickening was shown and a pleural calcification next to a rounded atelectasis was detected. Asbestos exposure could be excluded. In pulmonary function test a restrictive lung pattern could be revealed. In work samples scanning electron microscopy (SEM) including energy dispersive X-ray analysis (EDX) classified used fibres as aluminium silicate fibres. X-ray powder diffraction (XRD) and transmission electron microscopy (TEM) showed crystalline as well as amorphous fibres.
A comprehensive lung function analysis and in case of restrictive lung disorders additional CT scans are needed in RCF exposed workers in accordance to the guidelines for medical occupational examinations comparable to asbestos exposed workers.
refractory ceramic fibres (RCF) 是一种人造矿物纤维,用于高性能隔热应用。与石棉纤维类似,RCF 可吸入,具有胸膜漂移性,并在暴露后 20 多年内在人体肺组织中持续存在。已经报道了胸膜变化,例如局限性或弥漫性胸膜增厚以及胸膜钙化。
一名 45 岁的男子从事高性能隔热应用工作,使用 refractory ceramic fibres (RCF) 近 20 年。在职业医学预防措施中,使用 X 射线包括高分辨率计算机断层扫描 (HRCT) 来确保早期诊断因吸入硅酸铝纤维引起的疾病,显示双侧胸膜增厚,并在圆形肺不张旁边检测到胸膜钙化。可以排除石棉暴露。肺功能测试显示出限制性肺模式。在工作样本扫描电子显微镜 (SEM) 中,包括能量色散 X 射线分析 (EDX) 将使用的纤维分类为硅酸铝纤维。X 射线粉末衍射 (XRD) 和透射电子显微镜 (TEM) 显示出结晶和无定形纤维。
根据与石棉暴露工人相当的医疗职业检查指南,在 RCF 暴露工人中,需要进行全面的肺功能分析,并且在存在限制性肺疾病的情况下,需要额外进行 CT 扫描。