Pocecco M, Barbi E, De Campo C
Pediatr Med Chir. 1986 Sep-Oct;8(5):691-4.
Eight children with Graves' disease and five children with Hashimoto's thyroiditis admitted to the Pediatric Department of the University of Trieste in the period 1980 to 1985 have been reviewed. The purpose of this study was to define the clinical course of autoimmune thyroid diseases and to evaluate the frequency of HLA haplotypes and immunological abnormalities in the affected patients and in their family members. Antithyroid microsomal antibodies were observed in 87.5% of the hyperthyroid patients and in 13.3% of their siblings and parents, in all the patients affected by Hashimoto's thyroiditis and in 18.18% of their first degree relatives. HLA A1-B8 was found to be associated with Graves' disease, HLA B35 was linked to chronic lymphocytic thyroiditis. Using monoclonal antibodies for enumeration of the subsets of T lymphocytes a deficit in suppressor T-cells was demonstrated in subjects affected by autoimmune thyroid diseases as in other immunological disorders.
对1980年至1985年间收治于的里雅斯特大学儿科的8名格雷夫斯病患儿和5名桥本甲状腺炎患儿进行了回顾性研究。本研究的目的是确定自身免疫性甲状腺疾病的临床病程，并评估受影响患者及其家庭成员中HLA单倍型和免疫异常的频率。在87.5%的甲状腺功能亢进患者及其13.3%的兄弟姐妹和父母中观察到抗甲状腺微粒体抗体，在所有桥本甲状腺炎患者及其18.18%的一级亲属中也观察到该抗体。发现HLA A1 - B8与格雷夫斯病相关，HLA B35与慢性淋巴细胞性甲状腺炎相关。使用单克隆抗体对T淋巴细胞亚群进行计数，结果表明，与其他免疫疾病一样，自身免疫性甲状腺疾病患者存在抑制性T细胞缺陷。
