Kazan Institute of Biochemistry and Biophysics, FRC Kazan Science Center, Russian Academy of Sciences, Kazan, Russia.
Kazan (Volga Region) Federal University, Kazan, Russia.
Dokl Biochem Biophys. 2021 Nov;501(1):444-448. doi: 10.1134/S1607672921060028. Epub 2021 Dec 29.
For the first time it was shown that the development of resistance to ciprofloxacin in vitro in Acholeplasma laidlawii, a mycoplasma which is widely spread in nature and which is the main contaminant of cell cultures and vaccines, is associated with diverse pathways of virulence evolution: virulome and virulence differ significantly between ciprofloxacin-resistant strains, including those with the same level of antimicrobial resistance.
首次表明，在自然界广泛存在且是细胞培养物和疫苗主要污染物的支原体 Acholeplasma laidlawii 中，体外对环丙沙星的耐药性发展与多种毒力进化途径有关：包括具有相同抗菌耐药水平的耐药株在内，毒力基因组和毒力存在显著差异。
