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支原体对抗生素肽的适应：无壁支原体对蜂毒素耐药性的产生与基因组和蛋白质组谱的变化以及毒力有关。

Adaptation of Mycoplasmas to Antimicrobial Peptides: Development of Melittin Resistance in Acholeplasma laidlawii Is Associated with Changes in Genomic and Proteomic Profiles and in Virulence.

机构信息

Kazan Institute of Biochemistry and Biophysics, Federal Research Center Kazan Science Center of the Russian Academy of Sciences, Kazan, Russia.

Kazan (Volga Region) Federal University, Kazan, Russia.

出版信息

Dokl Biochem Biophys. 2020 Nov;495(1):300-303. doi: 10.1134/S1607672920060034. Epub 2020 Dec 25.

DOI:10.1134/S1607672920060034
PMID:33368039
Abstract

For the first time it is shown that the development of resistance to melittin in Acholeplasma laidlawii, a mycoplasma that is widely spread in nature and that is the main contaminant of cell cultures and vaccines, is associated with significant changes in the genomic profile, in cellular and vesicular proteomes, as well as in virulence.

摘要

首次表明，阿氏通体（广泛存在于自然界中，也是细胞培养物和疫苗的主要污染物）对蜂毒素产生抗性的发展与基因组图谱、细胞和囊泡蛋白质组以及毒力的显著变化有关。

相似文献

1
Adaptation of Mycoplasmas to Antimicrobial Peptides: Development of Melittin Resistance in Acholeplasma laidlawii Is Associated with Changes in Genomic and Proteomic Profiles and in Virulence.支原体对抗生素肽的适应：无壁支原体对蜂毒素耐药性的产生与基因组和蛋白质组谱的变化以及毒力有关。
Dokl Biochem Biophys. 2020 Nov;495(1):300-303. doi: 10.1134/S1607672920060034. Epub 2020 Dec 25.
2
Adaptation to Antimicrobials and Pathogenicity in Mycoplasmas: Development of Ciprofloxacin-Resistance and Evolution of Virulence in Acholeplasma laidlawii.支原体对抗微生物药物和致病性的适应：环丙沙星耐药性的发展和无壁菌 laidlawii 毒力的进化。
Dokl Biochem Biophys. 2021 Nov;501(1):444-448. doi: 10.1134/S1607672921060028. Epub 2021 Dec 29.
3
Data on proteomic profiling of cells and extracellular vesicles of the melittin-resistant strain.蜂毒肽抗性菌株的细胞和细胞外囊泡的蛋白质组学分析数据。
Data Brief. 2019 Jun 21;25:104169. doi: 10.1016/j.dib.2019.104169. eCollection 2019 Aug.
4
[Cytotoxic activity of melittin expressed by recombinant vectors in Acholeplasma laidlawii and Mycoplasma hominis cells].[重组载体表达的蜂毒素在莱氏无胆甾原体和人型支原体细胞中的细胞毒性活性]
Genetika. 2001 Jan;37(1):46-53.
5
Genomic and proteomic profiles of Acholeplasma laidlawii strains differing in sensitivity to ciprofloxacin.对环丙沙星敏感性不同的莱氏无胆甾原体菌株的基因组和蛋白质组图谱。
Dokl Biochem Biophys. 2016;466:23-7. doi: 10.1134/S1607672916010075. Epub 2016 Mar 31.
6
Extracellular membrane vesicles secreted by mycoplasma Acholeplasma laidlawii PG8 are enriched in virulence proteins.莱氏无胆甾原体PG8分泌的细胞外膜泡富含毒力蛋白。
J Proteomics. 2014 Oct 14;110:117-28. doi: 10.1016/j.jprot.2014.07.020. Epub 2014 Jul 31.
7
Adaptation of mycoplasmas to antimicrobial agents: Acholeplasma laidlawii extracellular vesicles mediate the export of ciprofloxacin and a mutant gene related to the antibiotic target.支原体对抗菌药物的适应性：莱氏无胆甾原体细胞外囊泡介导环丙沙星及与抗生素靶点相关的突变基因的输出。
ScientificWorldJournal. 2014 Jan 29;2014:150615. doi: 10.1155/2014/150615. eCollection 2014.
8
Unadapted and adapted to starvation Acholeplasma laidlawii cells induce different responses of Oryza sativa, as determined by proteome analysis.未适应和适应饥饿的 Acholeplasma laidlawii 细胞通过蛋白质组分析诱导不同的 Oryza sativa 反应。
J Proteomics. 2011 Nov 18;74(12):2920-36. doi: 10.1016/j.jprot.2011.07.016. Epub 2011 Jul 30.
9
[Effect of heat shock on cells of phytopathogenic mycoplasma Acholeplasma laidlawii PG-8A].[热休克对植物病原支原体莱氏无胆甾原体PG-8A细胞的影响]
Tsitologiia. 2015;57(1):5-13.
10
Adaptation of mycoplasmas to environmental conditions: features of the proteome shift in Acholeplasma laidlawii PG8 at persistent exposure to stressors.
Dokl Biochem Biophys. 2011 May-Jun;438:134-7. doi: 10.1134/S1607672911030057. Epub 2011 Jul 3.

本文引用的文献

1
Data on proteomic profiling of cells and extracellular vesicles of the melittin-resistant strain.蜂毒肽抗性菌株的细胞和细胞外囊泡的蛋白质组学分析数据。
Data Brief. 2019 Jun 21;25:104169. doi: 10.1016/j.dib.2019.104169. eCollection 2019 Aug.
2
Efficacy of Antibacterial Peptides Against Peptide-Resistant MRSA Is Restored by Permeabilization of Bacteria Membranes.抗菌肽对肽抗性耐甲氧西林金黄色葡萄球菌的疗效可通过细菌细胞膜的通透化作用得以恢复。
Front Microbiol. 2016 Nov 8;7:1745. doi: 10.3389/fmicb.2016.01745. eCollection 2016.
3
Extracellular membrane vesicles secreted by mycoplasma Acholeplasma laidlawii PG8 are enriched in virulence proteins.
莱氏无胆甾原体PG8分泌的细胞外膜泡富含毒力蛋白。
J Proteomics. 2014 Oct 14;110:117-28. doi: 10.1016/j.jprot.2014.07.020. Epub 2014 Jul 31.
4
Interaction of cationic antimicrobial peptides with Mycoplasma pulmonis.阳离子抗菌肽与肺炎支原体的相互作用。
FEBS Lett. 2013 Oct 11;587(20):3321-6. doi: 10.1016/j.febslet.2013.08.016. Epub 2013 Aug 28.
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Bacterial charity work leads to population-wide resistance.细菌慈善工作导致人群广泛耐药。
Nature. 2010 Sep 2;467(7311):82-5. doi: 10.1038/nature09354.
6
Resistance to antimicrobial peptides and stress response in Mycoplasma pulmonis.肺炎支原体对抗菌肽的抗性及应激反应
Antimicrob Agents Chemother. 2005 Oct;49(10):4154-65. doi: 10.1128/AAC.49.10.4154-4165.2005.
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[Chromosome aberrations induced by mycoplasma infections in human peripheral blood lymphocytes].
Genetika. 1996 Jun;32(6):810-4.