Lindemann Charles B
Department of Biological Sciences, Oakland University, Rochester, Michigan.
Bioessays. 2022 Mar;44(3):e2100143. doi: 10.1002/bies.202100143. Epub 2021 Dec 29.
This essay presents a hypothesis which contends that the development of organismic complexity in the eukaryotes depended extensively on propagation via flagellated and ciliated gametes. Organisms utilizing flagellate and ciliate gametes to propagate their germ line have contributed most of the organismic complexity found in the higher animals. The genes of the flagellum and the flagellar assembly system (intraflagellar transport) have played a disproportionately important role in the construction of complex tissues and organs. The hypothesis also proposes that competition between large numbers of haploid flagellated male gametes rigorously conserved the functionality of a key set of flagellar genes for more than 700 million years. This in turn has insured that a large set (>600) of highly functional cytoskeletal and signal pathway genes is always present in the lineage of organisms with flagellated or ciliated gametes to act as a dependable resource, or "toolkit," for organ elaboration. Also see the video abstract here: https://youtu.be/lC5nC-WOcm8.
本文提出了一种假说，认为真核生物中生物体复杂性的发展在很大程度上依赖于通过有鞭毛和纤毛的配子进行繁殖。利用有鞭毛和纤毛的配子来繁殖其种系的生物体，对高等动物中发现的大部分生物体复杂性都有贡献。鞭毛和鞭毛组装系统（鞭毛内运输）的基因在复杂组织和器官的构建中发挥了极其重要的作用。该假说还提出，大量单倍体有鞭毛雄配子之间的竞争在超过7亿年的时间里严格地保留了一组关键鞭毛基因的功能。这反过来又确保了在有鞭毛或纤毛配子的生物谱系中始终存在大量（>600个）高度功能性的细胞骨架和信号通路基因，作为器官精细构建的可靠资源或“工具包”。另请在此处查看视频摘要：https://youtu.be/lC5nC-WOcm8 。
