显微镜结肠炎与结直肠腺瘤和癌症风险降低相关：一项荟萃分析。

Microscopic Colitis Is Associated With a Reduced Risk of Colorectal Adenoma and Cancer: A Meta-Analysis.

机构信息

Department of Gastroenterology, Hospital of Hangzhou Red Cross, Hangzhou, China.

Department of Integrative Medicine Oncology, Hangzhou Tianmushan Hospital, Hangzhou, China.

出版信息

Inflamm Bowel Dis. 2022 Oct 3;28(10):1584-1591. doi: 10.1093/ibd/izab333.

DOI:10.1093/ibd/izab333

PMID:34967413

Abstract

BACKGROUND

The study sought to conduct a systematic review and meta-analysis of the risk of colorectal adenoma or cancer in patients with microscopic colitis (MC).

METHODS

A comprehensive literature search of PubMed and EMBASE databases was performed. Pooled relative risks (RRs) and 95% confidence intervals (CIs) were calculated to examine the effect of MC on the risk of colorectal adenoma or cancer.

RESULTS

Twelve studies reporting the outcomes of 50 795 patients with MC were eligible for this meta-analysis. MC was negatively associated with the risk of colorectal adenoma compared with participants without MC (RR, 0.44; 95% CI, 0.33-0.58; P < .001; I2 = 87.3%). Also, the rate of colorectal cancer was lower in the patients with MC compared with the general population (RR, 0.62; 95% CI, 0.43-0.89; P = .01; I2 = 91.6%). In addition, sensitivity and subgroup analyses indicated that the results were robust.

CONCLUSIONS

The present systematic review indicated that patients with MC may be associated with a lower risk of colorectal adenoma or cancer. The clinical data support the current professional society guideline. A surveillance colonoscopy program is not recommended as standard for patients with MC.

摘要

背景

本研究旨在对显微镜结肠炎（MC）患者发生结直肠腺瘤或癌症的风险进行系统评价和荟萃分析。

方法

对 PubMed 和 EMBASE 数据库进行全面文献检索。计算汇总相对风险（RR）和 95%置信区间（CI），以评估 MC 对结直肠腺瘤或癌症风险的影响。

结果

共有 12 项研究报告了 50795 例 MC 患者的结局，符合本荟萃分析的纳入标准。与无 MC 的参与者相比，MC 与结直肠腺瘤的风险呈负相关（RR，0.44；95%CI，0.33-0.58；P<0.001；I2=87.3%）。此外，MC 患者的结直肠癌发生率低于普通人群（RR，0.62；95%CI，0.43-0.89；P=0.01；I2=91.6%）。此外，敏感性和亚组分析表明结果是稳健的。