Demiroglu Bilim University, Istanbul 34394, Turkey.
Exp Oncol. 2021 Dec;43(4):290-297. doi: 10.32471/exp-oncology.2312-8852.vol-43-no-4.16804.
Our knowledge about the etiology of cancer is increasing. Many studies show that non-intrinsic factors such as environment or lifestyle are the main risk factors for the occurrence of cancer. On the other hand, there are studies showing that the main risk factors in the occurrence of cancer are caused by DNA replication errors (known as the intrinsic factors). This view limits highly the possibility of protection from cancer. However, the findings obtained from the literature show that non-intrinsic factors contribute substantially to cancer risk and that cancer should be considered as a preventable disease. This review is aimed to examine the factors known as non-intrinsic cancer risk factors in the light of recent research.Key Words: cancer, non-intrinsic risk factors, cancer prevention.
我们对癌症病因的认识正在不断增加。许多研究表明，非内在因素，如环境或生活方式，是癌症发生的主要危险因素。另一方面，有研究表明，癌症发生的主要危险因素是由 DNA 复制错误引起的（称为内在因素）。这种观点极大地限制了预防癌症的可能性。然而，从文献中获得的研究结果表明，非内在因素在癌症风险中起着重要作用，癌症应该被视为一种可预防的疾病。本综述旨在根据最近的研究，探讨被称为非内在癌症危险因素的因素。
癌症、非内在危险因素、癌症预防。
