hsa-miR-21 及其靶基因在鼻咽癌中的作用。
The Role of hsa-miR-21 and Its Target Genes Involved in Nasopharyngeal Carcinoma.
机构信息
Faculty of Biotechnology, Ho Chi Minh City Open University, Ho Chi Minh City, Vietnam.
出版信息
Asian Pac J Cancer Prev. 2021 Dec 1;22(12):4075-4083. doi: 10.31557/APJCP.2021.22.12.4075.
OBJECTIVE
MicroRNAs (miRNAs) are key post-transcriptional regulators of protein translation in humans. They have an essential role in various cancers, including nasopharyngeal carcinoma (NPC). The abnormal expression of miR-21 has been proven to be associated with various types of cancers, including NPC, through its targets. This study provides a systematic view of the roles of miR-21 and its network of targets (hsa-miR-21-3p, hsa-miR-21-5p) that are associated with nasopharyngeal carcinoma.
METHODS
Bioinformatics tools were applied to predict the targets of miR-21. Interactions among the targets of hsa-miR-21-3p/5p were found by the gene MANIA online tool.
RESULTS AND CONCLUSION
It was found that the target genes are involved in vital biological processes in cancer. In detail, a total of 95 targets of miR-21 were recorded to be associated with NPC. Therefore, they may provide new insights into nasopharyngeal pathogenesis and bring about novel targets for NPC diagnosis as well as therapy in near future.
目的
微小 RNA（miRNA）是人类蛋白质翻译过程中的关键转录后调控因子。它们在各种癌症中具有重要作用，包括鼻咽癌（NPC）。miR-21 的异常表达已被证明通过其靶标与包括 NPC 在内的多种癌症有关。本研究通过 miR-21 及其靶基因网络（hsa-miR-21-3p、hsa-miR-21-5p）系统地研究了与鼻咽癌相关的 miR-21 的作用。
方法
应用生物信息学工具预测 miR-21 的靶基因。通过在线工具 gene MANIA 发现 hsa-miR-21-3p/5p 靶基因之间的相互作用。
结果与结论
研究发现，靶基因参与癌症中的重要生物学过程。具体而言，共记录了 95 个与 NPC 相关的 miR-21 靶基因。因此，它们可能为鼻咽癌的发病机制提供新的见解，并为 NPC 的诊断和治疗带来新的靶点。
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