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hsa-mir-21 预测靶基因在肾透明细胞癌中的转录表达及免疫特征的综合分析。

Comprehensive Analysis of Transcriptional Expression of hsa-mir-21 Predicted Target Genes and Immune Characteristics in Kidney Renal Clear Cell Carcinoma.

机构信息

Department of Urological Surgery, Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China.

Department of Hematology, Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China.

出版信息

Int J Med Sci. 2022 Aug 21;19(9):1482-1501. doi: 10.7150/ijms.73404. eCollection 2022.

DOI:10.7150/ijms.73404
PMID:36035369
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9413563/
Abstract

To uncover advanced prognosis biomarkers in patient with kidney renal clear cell carcinoma (KIRC), our study was the first to make a comprehensive analysis of hsa-mir-21 predicted target genes and explore the immune characteristics in KIRC. In this study, the comprehensive analysis of hsa-mir-21 predicted target genes and immune characteristics in KIRC were analyzed via TIMER2.0, UALCAN, Metascape, Kaplan-Meier plotter, Human Protein Atlas, CancerSEA, JASPAR, GEPIA, R package: GSVA package (version 1.34.0) & immune infiltration algorithm (ssGSEA) and R package: RMS package (version 6.2-0) & SURVIVAL package (version 3.2-10). Up-transcriptional expressions of RP2, NFIA, SPRY1 were significantly associated with favorable prognosis in KIRC, whereas that of TGFBI was markedly significantly to unfavorable prognosis. Additionally, RP2, NFIA, SPRY1 and TGFBI were significantly relevant to the immune infiltration in KIRC. Finally, ZNF263 was a common predicted transcription factor of RP2, NFIA, SPRY1 and TGFBI, which can as an independent indicator for prognosis in KIRC patients. Hsa-mir-21 predicted target genes (RP2, NFIA, SPRY1 and TGFBI) and the common transcription factor ZNF263 could be the advanced prognosis biomarkers in KIRC patients.

摘要

为了在肾透明细胞癌（KIRC）患者中发现先进的预后生物标志物，我们的研究首次对 hsa-mir-21 预测靶基因进行了全面分析，并探讨了 KIRC 中的免疫特征。在这项研究中，通过 TIMER2.0、UALCAN、Metascape、Kaplan-Meier plotter、Human Protein Atlas、CancerSEA、JASPAR、GEPIA、R 包：GSVA 包（版本 1.34.0）和免疫浸润算法（ssGSEA）以及 R 包：RMS 包（版本 6.2-0）和 SURVIVAL 包（版本 3.2-10）分析了 KIRC 中 hsa-mir-21 预测靶基因和免疫特征的综合分析。RP2、NFIA、SPRY1 的上转录表达与 KIRC 的预后良好显著相关，而 TGFBI 则与预后不良显著相关。此外，RP2、NFIA、SPRY1 和 TGFBI 与 KIRC 的免疫浸润显著相关。最后，ZNF263 是 RP2、NFIA、SPRY1 和 TGFBI 的常见预测转录因子，可作为 KIRC 患者预后的独立指标。Hsa-mir-21 预测靶基因（RP2、NFIA、SPRY1 和 TGFBI）和共同转录因子 ZNF263 可能是 KIRC 患者的先进预后生物标志物。

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