Kim M K, Chan C C, Belfort R, Farah M, Burnier M P, Nussenblatt R B, Kuwabara T, Palestine A G
Am J Ophthalmol. 1987 Jul 15;104(1):15-23. doi: 10.1016/0002-9394(87)90287-x.
We studied histopathologic and immunohistopathologic features of an eye from a patient who had hypopigmented choroidal lesions with subsequent development of progressive subretinal fibrotic tissue associated with minimal signs of vitreal inflammation. A 24-year-old woman had a rapid and severe onset of the disease, which led to blindness within a few months despite treatment with corticosteroids and cyclophosphamide. Histopathologic studies disclosed a marked gliotic retina and thick subretinal fibrotic tissue as well as a granulomatous lymphocytic infiltration in the choroid. Electron microscopy demonstrated that the subretinal tissue was derived from retinal pigment epithelial cells. The immunoperoxidase staining showed similar proportions of T and B lymphocytes, indicating a relative increase of B cells. There was a predominance of the helper/inducer T lymphocyte subset in the infiltrating area. The Müller cells in the retina expressed class II antigens of the major histocompatibility complex.
我们研究了一名患者眼部的组织病理学和免疫组织病理学特征，该患者有脉络膜色素减退性病变，随后出现进行性视网膜下纤维化组织，并伴有轻微的玻璃体炎症迹象。一名24岁女性疾病起病迅速且严重，尽管接受了皮质类固醇和环磷酰胺治疗，但在几个月内就导致失明。组织病理学研究显示视网膜明显胶质化、视网膜下纤维化组织增厚以及脉络膜有肉芽肿性淋巴细胞浸润。电子显微镜检查表明视网膜下组织源自视网膜色素上皮细胞。免疫过氧化物酶染色显示T淋巴细胞和B淋巴细胞比例相似，表明B细胞相对增多。浸润区域中辅助/诱导性T淋巴细胞亚群占优势。视网膜中的Müller细胞表达主要组织相容性复合体的II类抗原。
