Department of Dermatology, Konya Ereğli State Hospital, Konya, Turkey.
Meram Medical Faculty, Department of Dermatology, Necmettin Erbakan University, Konya, Turkey.
Cutan Ocul Toxicol. 2022 Mar;41(1):60-66. doi: 10.1080/15569527.2021.2024565. Epub 2022 Jan 9.
Dapsone is a "4,4'-diamino diphenyl sulfone" compound and an aniline derivative from synthetic sulphones. Sulphonamides were first used in humans as antimicrobial agents to treat streptococcal infections. Dapsone derived from sulphonamides was first used in the treatment of leprosy in 1940. Today, Dapsone treatment is among the treatment options for many dermatological diseases. Acne vulgaris is a chronic inflammatory disease, which causes scar formation and changed pigmentation. Acne affects 85% of teenagers, but can occur at any age and can last into adulthood and even lifelong. Through its antimicrobial, anti-inflammatory, and antioxidant effects, dapsone treatment (local or systemic) can also be used in the treatment of acne. Dapsone treatment can cause a variety of side effects that can be categorized as pharmacological, dose-related, allergic, or idiosyncratic reactions. In this review article, the risks and benefits of using dapsone treatment in acne vulgaris will be evaluated in light of the literature.
氨苯砜是一种“4,4'-二氨基二苯砜”化合物，是一种合成砜类药物的苯胺衍生物。磺胺类药物最初被人类用作抗生素，以治疗链球菌感染。1940 年，氨苯砜从磺胺类药物中分离出来，首次用于治疗麻风病。如今，氨苯砜治疗是许多皮肤科疾病的治疗选择之一。寻常痤疮是一种慢性炎症性疾病，可导致瘢痕形成和色素改变。痤疮影响 85%的青少年，但也可能在任何年龄发生，并持续到成年甚至终生。通过其抗菌、抗炎和抗氧化作用，氨苯砜治疗（局部或全身）也可用于治疗痤疮。氨苯砜治疗会引起多种副作用，可分为药理学、剂量相关、过敏或特发性反应。在这篇综述文章中，将根据文献评估氨苯砜治疗寻常痤疮的风险和益处。
