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皮肤病学中的局部抗生素治疗

Topical Antibiotic Treatment in Dermatology.

作者信息

Dallo Matthew, Patel Kavina, Hebert Adelaide A

机构信息

Department of Dermatology, The University of Texas Health Houston, Houston, TX 77030, USA.

Department of Dermatology and Pediatrics, The University of Texas Health Houston, Houston, TX 77030, USA.

出版信息

Antibiotics (Basel). 2023 Jan 17;12(2):188. doi: 10.3390/antibiotics12020188.

DOI:10.3390/antibiotics12020188
PMID:36830098
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9952385/
Abstract

Many indications in dermatology can be effectively managed with topical antibiotics, including acne vulgaris, wound infections, secondarily infected dermatitis, and impetigo. Dermatologists must be familiar with the wide spectrum of topical antibiotics available, including indications, mechanisms of action, adverse events, and spectra of activity. Dermatologists must also keep antibiotic resistance in mind when utilizing these medications. Due to the widespread use of topical antibiotics and their importance in dermatology, a literature review was performed using a systematic search of PubMed and Google Scholar with the terms topical antibiotics, skin infections, dermatology, antimicrobials, and inflammatory dermatoses to identify English-language articles published between 1965-2022 from any country. Relevant publications were manually reviewed for additional content. The following literature review will summarize the common topical antibiotics used in dermatology.

摘要

皮肤科的许多病症都可用外用抗生素有效治疗,包括寻常痤疮、伤口感染、继发性感染性皮炎和脓疱病。皮肤科医生必须熟悉现有的多种外用抗生素,包括其适应症、作用机制、不良事件和活性谱。皮肤科医生在使用这些药物时还必须考虑抗生素耐药性问题。由于外用抗生素的广泛使用及其在皮肤科的重要性,我们通过在PubMed和谷歌学术上使用“外用抗生素”“皮肤感染”“皮肤科”“抗菌药物”和“炎症性皮肤病”等关键词进行系统检索,以识别1965年至2022年间在任何国家发表的英文文章,从而进行了一项文献综述。对相关出版物进行了人工审阅以获取更多内容。以下文献综述将总结皮肤科常用的外用抗生素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2cf5/9952385/7c7a26e2d61d/antibiotics-12-00188-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2cf5/9952385/7c7a26e2d61d/antibiotics-12-00188-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2cf5/9952385/7c7a26e2d61d/antibiotics-12-00188-g001.jpg

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JAMA Dermatol. 2022 Sep 1;158(9):989-991. doi: 10.1001/jamadermatol.2022.3168.
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Inducible Clindamycin-Resistant Strains in Africa: A Systematic Review.非洲的可诱导克林霉素耐药菌株:一项系统评价
Int J Microbiol. 2022 Apr 19;2022:1835603. doi: 10.1155/2022/1835603. eCollection 2022.
3
Dapsone for the treatment of acne vulgaris: do the risks outweigh the benefits?氨苯砜治疗寻常痤疮:风险大于获益吗?
源自两栖动物的肽TB_KKG6K的抗菌活性及治疗潜力
mSphere. 2025 Jun 25;10(6):e0101624. doi: 10.1128/msphere.01016-24. Epub 2025 May 19.
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Hydrogel Containing Biogenic Silver Nanoparticles and Essential Oil for Burn Wounds: Antimicrobial Efficacy Using Ex Vivo and In Vivo Methods Against Multidrug-Resistant Microorganisms.含生物源银纳米颗粒和精油的水凝胶用于烧伤创面:采用体外和体内方法对多重耐药微生物的抗菌效果
Pharmaceutics. 2025 Apr 10;17(4):503. doi: 10.3390/pharmaceutics17040503.
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Development and Evaluation of Azithromycin-Loaded Transethosomes for Enhanced Dermal Delivery and Antibacterial Efficacy.载阿奇霉素转质体用于增强皮肤给药及抗菌效果的研发与评价
Pharmaceutics. 2025 Mar 21;17(4):400. doi: 10.3390/pharmaceutics17040400.
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Topical administration of mupirocin ointment and fusidic acid in bacterial infection-induced skin diseases.莫匹罗星软膏和夫西地酸在细菌感染性皮肤病中的局部应用。
Postepy Dermatol Alergol. 2025 Feb;42(1):42-46. doi: 10.5114/ada.2024.145185. Epub 2024 Nov 19.
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