Collins A J, Du Toit J A
Br J Rheumatol. 1987 Aug;26(4):295-8. doi: 10.1093/rheumatology/26.4.295.
An upper gastrointestinal endoscopic examination was performed, following a test for faecal occult blood, on a group of 108 patients with rheumatic complaints. The majority of the group studied had rheumatoid arthritis (RA) and 50% of the total group were anaemic. Every patient was taking a single nonsteroidal anti-inflammatory drug (NSAID). When the finding of blood in the faeces was compared with findings in the upper gastrointestinal tract, approximately half the subjects with ulcerative and inflammatory lesions had a positive test for blood. However, 50% of the subjects with an apparently normal upper gastrointestinal tract had a positive test for blood in the stool and these comprised the largest group of those examined. It was concluded that the finding of a positive faecal occult blood in such subjects is a poor indicator of ulcerative or inflammatory lesions of the upper gastrointestinal tract. The possible reasons for a finding of blood in the stool of patients taking NSAID who apparently have a normal upper gastrointestinal tract is discussed.
对一组108例有风湿性疾病主诉的患者进行了粪便潜血试验后，进行了上消化道内镜检查。研究组中的大多数患者患有类风湿关节炎（RA），且整个组中有50%的患者贫血。每位患者都在服用单一的非甾体抗炎药（NSAID）。当将粪便中发现血液的情况与上消化道的检查结果进行比较时，约一半有溃疡性和炎性病变的受试者粪便潜血试验呈阳性。然而，50%上消化道明显正常的受试者粪便潜血试验呈阳性，且这些受试者构成了受检者中的最大群体。得出的结论是，在这类受试者中粪便潜血阳性的发现对上消化道溃疡性或炎性病变来说并非一个可靠指标。文中讨论了服用NSAID但上消化道明显正常的患者粪便中出现血液的可能原因。
