术前咬肌肌少症预测食管癌患者的死亡率。

Preoperative Masseter Muscle Sarcopenia Predicts Mortality in Patients With Oesophageal Cancer.

机构信息

Department of Surgery, International University of Health and Welfare Hospital, Tochigi, Japan

Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan.

出版信息

Anticancer Res. 2022 Jan;42(1):301-310. doi: 10.21873/anticanres.15486.

DOI:10.21873/anticanres.15486

PMID:34969738

Abstract

BACKGROUND/AIM: The impact of masseter muscle sarcopenia on the prognosis of patients with oesophageal cancer after oesophagectomy remains unclear.

PATIENTS AND METHODS

We retrospectively analysed data from 70 patients with oesophageal cancer who underwent oesophagectomy between 2013 and 2019. Overall survival and disease-free survival rates were analysed using Cox proportional hazards models and Kaplan-Meier curves with the log-rank test.

RESULTS

Masseter muscle sarcopenia was diagnosed in 36 patients. Multivariate analysis identified cytokeratin 19 fragment >1.1 (p=0.04); stage II, III, and IV cancer (p=0.01); and masseter muscle sarcopenia (p<0.01) as significant independent predictors of disease-free survival. Stage II, III, and IV cancer (p<0.01); masseter muscle sarcopenia (p<0.01); and postoperative pneumonia (p<0.01) were significant independent predictors of overall survival.

CONCLUSION

Preoperative masseter muscle sarcopenia could be a strong predictor of long-term outcomes in patients who undergo oesophagectomy for oesophageal cancer.

摘要

背景/目的：咀嚼肌肌少症对食管癌患者食管癌手术后的预后影响尚不清楚。

患者和方法

我们回顾性分析了 2013 年至 2019 年间接受食管癌切除术的 70 例食管癌患者的数据。使用 Cox 比例风险模型和 Kaplan-Meier 曲线与对数秩检验分析总生存率和无病生存率。

结果

36 例患者被诊断为咀嚼肌肌少症。多变量分析确定细胞角蛋白 19 片段>1.1（p=0.04）；II 期、III 期和 IV 期癌症（p=0.01）；以及咀嚼肌肌少症（p<0.01）是无病生存率的显著独立预测因素。II 期、III 期和 IV 期癌症（p<0.01）；咀嚼肌肌少症（p<0.01）；以及术后肺炎（p<0.01）是总生存率的显著独立预测因素。