Department of Pathology, Kurume University School of Medicine, Kurume, Japan
Department of Diagnostic Pathology, Kurume University Hospital, Kurume, Japan.
Anticancer Res. 2022 Jan;42(1):449-457. doi: 10.21873/anticanres.15503.
BACKGROUND/AIM: Non-B non-C hepatocellular carcinomas (NBNC-HCCs) are larger than hepatitis virus-related HCCs. We conducted a clinicopathological study of patients who underwent curative NBNC-HCC resection, including proliferative activity assessments, such as nuclear grade and Ki-67 labelling index (LI).
Histopathological findings of 197 patients were examined, including 56 NBNC-HCCs, 45 hepatitis B virus (HBV)-related HCCs (HBV-HCC), and 96 hepatitis C virus (HCV)-related HCCs (HCV-HCC).
NBNC-HCCs were significantly larger than HCV-HCCs, but not significantly different from HBV-HCCs. Mitotic counts, nuclear grade, and Ki-67 LI of NBNC-HCCs were not significantly different from those of HCV-HCCs, but were significantly lower than those of HBV-HCCs. Recurrence-free survival was significantly better in the NBNC-HCC group than in the HBV-HCC group in cases with mild liver fibrosis.
NBNC-HCCs were significantly larger in diameter, but their nuclear grade or Ki-67 LI were not significantly different from those of other HCCs, suggesting that they do not have a higher proliferative activity.
背景/目的：非乙型肝炎、非丙型肝炎肝细胞癌（NBNC-HCC）比乙型肝炎病毒相关 HCC 更大。我们对接受根治性 NBNC-HCC 切除术的患者进行了临床病理研究，包括核级和 Ki-67 标记指数（LI）等增殖活性评估。
检查了 197 例患者的组织病理学发现，包括 56 例 NBNC-HCC、45 例乙型肝炎病毒（HBV）相关 HCC（HBV-HCC）和 96 例丙型肝炎病毒（HCV）相关 HCC（HCV-HCC）。
NBNC-HCC 明显大于 HCV-HCC，但与 HBV-HCC 无显著差异。NBNC-HCC 的有丝分裂计数、核级和 Ki-67 LI 与 HCV-HCC 无显著差异，但明显低于 HBV-HCC。在轻度肝纤维化的情况下，NBNC-HCC 组的无复发生存率明显优于 HBV-HCC 组。
NBNC-HCC 的直径明显更大，但核级或 Ki-67 LI 与其他 HCC 无显著差异，表明其增殖活性并不高。
