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器官移植的历史。

The history of organ transplantation.

作者信息

Nordham Kristen D, Ninokawa Scott

机构信息

Department of Surgery, Tulane University School of Medicine, New Orleans, Louisiana.

出版信息

Proc (Bayl Univ Med Cent). 2021 Oct 19;35(1):124-128. doi: 10.1080/08998280.2021.1985889. eCollection 2022.

Abstract

Since ancient times, mythology has included tales of creatures made of an amalgamation of others, transferring body parts and skin. In the 1950s, with no other medical options for then incurable diseases, including nephritis, teams of scientists, surgeons, and generous patients started the field of organ transplant with the first successful kidney transplant in a human. The scientific discoveries and innovations since that first successful transplant in 1954 have turned the mythical concept of transplant into reality. The overall success and public acceptance of organ donation and transplant today is thanks to multidisciplinary teams of basic scientists, immunologists, surgeons, and public advocates. Today, research is propelling the field forward with advancements like face transplants, experiments of lab-grown organs, and much more. In the United States alone, over 800,000 patients have had their lives saved or significantly improved thanks to transplant since national recording began by the Organ Procurement and Transplant Network in 1988.

摘要

自古以来,神话中就包含了由其他生物融合而成、能转移身体部位和皮肤的生物故事。20世纪50年代,对于包括肾炎在内的当时无法治愈的疾病,没有其他医疗选择,于是科学家团队、外科医生和慷慨的患者开启了器官移植领域,完成了首例人类肾脏移植并取得成功。自1954年首例移植成功以来的科学发现和创新,已将移植这一神话概念变为现实。如今,器官捐赠和移植的总体成功以及公众的接受度,要归功于基础科学家、免疫学家、外科医生和公众倡导者组成的多学科团队。如今,研究正推动该领域向前发展,例如面部移植、实验室培育器官的实验等等。仅在美国,自器官获取与移植网络于1988年开始全国记录以来,就有超过80万名患者因移植而挽救了生命或显著改善了生活。

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