Department of Medicine, University of Chicago, Chicago, IL, USA.
Yale J Biol Med. 2021 Dec 29;94(4):681-686. eCollection 2021 Dec.
Cystinuria, accounting for about 1-2% of kidney stones in adults, carries significant morbidity beginning at a young age [1]. Cystine stone formers have more stone events compared to other stone formers, as well as more surgical interventions, potentially contributing to faster progression to chronic kidney disease (CKD), and end-stage kidney disease (ESKD) [2]. Successful medical therapy for cystine stone formers may be limited by adherence to the extensive lifestyle changes and the adverse side effect profiles of some interventions, leading to decreased quality of life for these patients relative to other stone formers.
胱氨酸尿症约占成人肾结石的 1-2%，自幼年起即具有显著的发病率[1]。与其他结石形成者相比，胱氨酸结石形成者发生结石事件更多，接受手术干预也更多，这可能导致其更快进展为慢性肾脏病（CKD）和终末期肾病（ESKD）[2]。由于对某些干预措施的不良反应谱和广泛的生活方式改变的依从性有限，胱氨酸结石形成者的医学治疗可能受到限制，从而导致这些患者的生活质量相对其他结石形成者下降。
