Gupta P, Sodhi A
Int J Immunopharmacol. 1987;9(3):385-8. doi: 10.1016/0192-0561(87)90065-8.
The supernatants collected from cis-platin (2 micrograms, 5 micrograms, 10 micrograms, treated macrophage monolayers enhance the proliferation of thymocytes by a submitogenic concentration of con A (1 microgram/ml). The supernatants collected from the untreated macrophage monolayers show a gradual ten fold increase in the interleukin-1 (IL-1) activity during 30 min to 48 h incubation at 37 degrees C. Supernatants collected from macrophage monolayers treated with 2 micrograms/ml of cis-platin show only a marginal increase in IL-1 activity as compared to untreated monolayers. However, compared to controls, 30 to 40 fold increases in IL-1 activity were measured in supernatants collected from the macrophage monolayers incubated with 5, 10 and 20 micrograms/ml cis-platin at 37 degrees C. The IL-1 activity in supernatants collected from macrophage monolayers treated with cis platin and LPS are also compared.
从经顺铂（2微克、5微克、10微克）处理的巨噬细胞单层收集的上清液，能通过亚致有丝分裂浓度的刀豆球蛋白A（1微克/毫升）增强胸腺细胞的增殖。从未经处理的巨噬细胞单层收集的上清液，在37℃孵育30分钟至48小时期间，白细胞介素-1（IL-1）活性逐渐增加10倍。与未经处理的单层相比，从用2微克/毫升顺铂处理的巨噬细胞单层收集的上清液中，IL-1活性仅略有增加。然而，与对照组相比，在37℃下用5、10和20微克/毫升顺铂孵育的巨噬细胞单层收集的上清液中，IL-1活性增加了30至40倍。还比较了从用顺铂和脂多糖处理的巨噬细胞单层收集的上清液中的IL-1活性。
