小鼠巨噬细胞在体外经顺铂处理后细胞溶解因子的释放
Release of cytolytic factor(s) by murine macrophages in vitro on treatment with cis-platin.
作者信息
Sodhi A, Singh S M
出版信息
Int J Immunopharmacol. 1986;8(7):701-7. doi: 10.1016/0192-0561(86)90005-6.
PMID:3781708
Abstract
Supernatants collected from macrophage monolayers treated with cis-Platin lyse the tumor cells in vitro. In addition the cis-Platin treated macrophages are observed to show increased binding of tumor cells and also have a cytostatic effect on them. It is proposed that cis-Platin treatment of macrophages results in the release of cytolytic factor(s) with potent capacity to lyse the tumor cells in vitro.
摘要
从用顺铂处理的巨噬细胞单层收集的上清液在体外可裂解肿瘤细胞。此外，观察到经顺铂处理的巨噬细胞对肿瘤细胞的结合增加，并且对它们具有细胞抑制作用。有人提出，用顺铂处理巨噬细胞会导致释放具有强大能力在体外裂解肿瘤细胞的溶细胞因子。
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