Foster N L, VanDerSpek A F, Aldrich M S, Berent S, Hichwa R H, Sackellares J C, Gilman S, Agranoff B W
J Cereb Blood Flow Metab. 1987 Aug;7(4):415-20. doi: 10.1038/jcbfm.1987.84.
The effect of sedation induced by intravenous diazepam on cerebral glucose metabolic activity was examined with [18F]2-fluoro-2-deoxy-D-glucose (FDG) and positron emission tomography (PET) in five patients with probable Alzheimer's disease. Each subject was studied on 2 separate days: on one occasion at rest with eyes patched and ears open, and on the second when sedated with intravenous diazepam titrated to maintain stage II sleep by clinical and EEG criteria. Similar patterns of glucose uptake were observed in both the presence and the absence of sedation, but overall glucose utilization was depressed an average of 20% and was closely correlated with the amount of diazepam administered prior to the injection of FDG. The predominant temporoparietal hypometabolism and relative sparing of frontal metabolism observed in this disease are therefore not explained by differences in anxiety or activity level in this patient group. Utilization of diazepam sedation for PET study appears to be safe and may permit the study of patients otherwise unable to cooperate with FDG-PET procedures.
采用[18F]2-氟-2-脱氧-D-葡萄糖（FDG）和正电子发射断层扫描（PET）技术，对5例疑似阿尔茨海默病患者静脉注射地西泮诱导镇静后大脑葡萄糖代谢活性的影响进行了研究。每位受试者在2个不同日期接受检查：一次是在静息状态下，蒙眼且保持耳朵开放；另一次是静脉注射地西泮进行镇静，根据临床和脑电图标准将剂量滴定至维持II期睡眠状态。在有镇静和无镇静状态下均观察到相似的葡萄糖摄取模式，但总体葡萄糖利用率平均降低了20%，且与注射FDG前给予的地西泮剂量密切相关。因此，该疾病中观察到的主要颞顶叶代谢减退和额叶代谢相对保留，不能用该患者组焦虑或活动水平的差异来解释。地西泮镇静用于PET研究似乎是安全的，并且可能使那些原本无法配合FDG-PET程序的患者能够接受研究。
