Zhengzhou Cardiovascular Hospital and 7th People's Hospital of Zhengzhou, Zhengzhou, Henan Province, China; State key Laboratory of Medicinal Chemical Biology & Key Laboratory of Bioactive Materials (Ministry of Education), College of Life Sciences, Nankai University, Tianjin, China.
State key Laboratory of Medicinal Chemical Biology & Key Laboratory of Bioactive Materials (Ministry of Education), College of Life Sciences, Nankai University, Tianjin, China.
J Mol Cell Cardiol. 2022 Apr;165:40-53. doi: 10.1016/j.yjmcc.2021.12.010. Epub 2021 Dec 29.
Cardiovascular diseases (CVDs) are life-threatening diseases with high morbidity and mortality worldwide. Vascular bypass surgery is still the ultimate strategy for CVD treatment. Autografts are the gold standard for graft transplantation, but insufficient sources limit their widespread application. Therefore, alternative tissue engineered vascular grafts (TEVGs) are urgently needed. In this review, we summarize the major strategies for the preparation of vascular grafts, as well as the factors affecting their patency and tissue regeneration. Finally, the underlying mechanisms of vascular regeneration that are mediated by host cells are discussed.
心血管疾病（CVDs）是全球范围内具有高发病率和死亡率的危及生命的疾病。血管旁路手术仍然是 CVD 治疗的终极策略。自体移植物是移植物移植的金标准，但来源不足限制了其广泛应用。因此，迫切需要替代组织工程血管移植物（TEVGs）。在这篇综述中，我们总结了制备血管移植物的主要策略，以及影响其通畅性和组织再生的因素。最后，讨论了宿主细胞介导的血管再生的潜在机制。
