Tan Wen, Pan Tingrui, Wang Shengpeng, Li Peng, Men Yongfan, Tan Rui, Zhong Zhangfeng, Wang Yitao
School of Pharmacy, Lanzhou University, Lanzhou, Gansu 730000, China.
Suzhou Institute for Advanced Research, University of Science and Technology of China, Suzhou, Jiangsu 215123, China.
Food Chem. 2021 Dec 15;376:131860. doi: 10.1016/j.foodchem.2021.131860.
The edible and medicinal plants (EMPs) are becoming an abundant source for cancer prevention and treatment since the natural and healthy trend for modern human beings. Currently, there are more than one hundred species of EMPs widely used and listed by the national health commission of China, and most of them indicate immune or metabolic regulation potential in cancer treatment with numerous studies over the past two decades. In the present review, we focused on the metabolic influence in immunocytes and tumor microenvironment, including immune response, immunosuppressive factors and cancer cells, discussing the immunometabolic potential of EMPs in cancer treatment. There are more than five hundred references collected and analyzed through retrieving pharmacological studies deposited in PubMed by medical subject headings and the corresponding names derived from pharmacopoeia of China as a sole criterion. Finally, the immunometabolism modulation of EMPs was sketch out implying an immunometabolic control in cancer treatment.
由于现代人类追求天然健康的趋势，可食用和药用植物正成为预防和治疗癌症的丰富资源。目前，中国国家卫生健康委员会广泛使用并列出了一百多种可食用和药用植物，在过去二十年的众多研究中，它们中的大多数在癌症治疗中显示出免疫或代谢调节潜力。在本综述中，我们重点关注免疫细胞和肿瘤微环境中的代谢影响，包括免疫反应、免疫抑制因子和癌细胞，讨论可食用和药用植物在癌症治疗中的免疫代谢潜力。通过以医学主题词检索存于PubMed的药理学研究以及源自《中国药典》的相应名称作为唯一标准，收集并分析了五百多篇参考文献。最后，勾勒出可食用和药用植物的免疫代谢调节，这意味着在癌症治疗中进行免疫代谢控制。
