Department of Neuroscience DNS, Otolaryngology Section, University of Padova, Padova, Italy.
Department of Cardiac-Thoracic-Vascular Sciences and Public Health, University of Padova, Padova, Italy.
Am J Otolaryngol. 2022 Mar-Apr;43(2):103342. doi: 10.1016/j.amjoto.2021.103342. Epub 2021 Dec 21.
Sex and age of patients are variables affecting across the board all chronic rhinosinusitis with nasal polyps (CRSwNP) endotypes. The main aim of this investigation was to compare the clinical, laboratory, pathological and prognostic characteristics of CRSwNP in male vs female patients stratified according to age (young-adult [20 years ≤ age ≤ 40 years], and elderly [age ≥ 65 years]). This is the first study that analyzed the association of the above-mentioned features with age and sex combination in CRSwNP electing endoscopic sinus surgery (ESS).
One hundred and five consecutive young-adult patients (62 males and 43 females) and 67 elderly patients (44 males and 23 females) with CRSwNP who had undergone ESS were enrolled.
The recurrence rate resulted associated with the age and sex combination (p = 0.0165). Young-adult males' recurrence rate (29.0%) was higher than young-adult females (11.6%) and elderly males (4.5%). Allergy resulted associated with age and sex combination (p = 0.0158). Young-adult males' allergy rate (50.0%) was higher than elderly males' (29.5%) and elderly females' (13%). Moreover, allergy rate was higher in young-adult females (41.9%) than in elderly females.
Our data suggest the possibility of an interaction between sex and age in the recurrence of nasal polyposis after ESS. More studies are needed to understand the role of sex hormones in pathogenesis and prognosis of CRSwNP.
患者的性别和年龄是影响所有慢性鼻-鼻窦炎伴鼻息肉（CRSwNP）表型的普遍变量。本研究的主要目的是比较根据年龄（青年成年人[20 岁≤年龄≤40 岁]和老年[年龄≥65 岁]）分层的男性和女性患者中 CRSwNP 的临床、实验室、病理和预后特征。这是第一项分析上述特征与 CRSwNP 内镜鼻窦手术（ESS）中年龄和性别组合关联的研究。
共纳入 105 例青年成年人（62 名男性和 43 名女性）和 67 例老年患者（44 名男性和 23 名女性），这些患者均患有 CRSwNP，并接受 ESS。
复发率与年龄和性别组合相关（p=0.0165）。青年成年男性的复发率（29.0%）高于青年成年女性（11.6%）和老年男性（4.5%）。过敏与年龄和性别组合相关（p=0.0158）。青年成年男性的过敏率（50.0%）高于老年男性（29.5%）和老年女性（13%）。此外，青年成年女性的过敏率（41.9%）高于老年女性。
我们的数据提示 ESS 后鼻息肉复发可能存在性别和年龄的相互作用。需要进一步的研究来了解性激素在 CRSwNP 发病机制和预后中的作用。
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