Medical School, University of Pécs, Pécs, Hungary;
Harkány Termal Rehabilitation Centre, Harkány, Hungary.
In Vivo. 2022 Jan-Feb;36(1):294-305. doi: 10.21873/invivo.12702.
BACKGROUND/AIM: Manual therapy (MT) is a frequently applied intervention offering individualized treatment in the clinic. In addition to the traditional approaches of MT, measuring molecular response to MT may offer better understanding of MT outcomes in order to provide specific personalized treatment. The aim of this study was to summarize MT-related registered clinical trials, as well as to search for any evidence on MT and genetics.
A comprehensive search was conducted within the Clinical Trials database with predefined keywords mining for all types of MT-related clinical trials.
From the 47 trials, 20 had results and 27 had no results. MT alleviated pain and improved function almost in all trials. One registered clinical trial had investigated molecular outcomes of MT.
MT is an effective and individualized treatment offering option in the management of several conditions. Interestingly, a clinical trial was found investigating molecular genetics and MT pinpointing an already existing link between genetics and MT. Therefore, further clinical trials may focus on genetics and MT for providing specific personalized treatment in future.
背景/目的：手法治疗（MT）是一种在临床上经常应用的干预方法，提供个体化治疗。除了传统的 MT 方法外，测量 MT 的分子反应可能有助于更好地了解 MT 的结果，以便提供特定的个性化治疗。本研究的目的是总结与 MT 相关的已注册临床试验，并搜索有关 MT 和遗传学的任何证据。
在临床试验数据库中进行了全面的搜索，使用预定义的关键字挖掘所有类型的 MT 相关临床试验。
在 47 项试验中，有 20 项有结果，27 项没有结果。MT 几乎在所有试验中都能缓解疼痛和改善功能。一项已注册的临床试验研究了 MT 的分子结果。
MT 是一种有效的、个体化的治疗方法，为多种疾病的治疗提供了选择。有趣的是，有一项临床试验正在研究分子遗传学和 MT，指出了遗传学和 MT 之间已经存在的联系。因此，未来的临床试验可能会集中在遗传学和 MT 上，为未来提供特定的个性化治疗。
