磁共振成像/超声融合引导前列腺穿刺活检中假阳性病变的组织病理学分析。
Histopathological Analysis of False-positive Lesions in mpMRI/TRUS Fusion Prostate Biopsy.
机构信息
Department of Urology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Department of Urology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan;
出版信息
In Vivo. 2022 Jan-Feb;36(1):496-500. doi: 10.21873/invivo.12730.
BACKGROUND/AIM: Multi-parametric magnetic resonance imaging (mpMRI)/ultrasonography fusion prostate biopsy (FB) is a more accurate method of diagnosis than conventional prostate biopsy, but false-positive lesions still exist. Limited studies have examined the cause of false-positive lesions by histological analysis.
PATIENTS AND METHODS
We examined 322 patients who underwent mpMRI/transrectal ultrasonography (TRUS) FB. We classified prostate imaging-recording and data system (PI-RADS) 3 and PI-RADS 4-5 as low PI-RADS lesions and high PI-RADS lesions, respectively. In total, 105 lesions were identified as false-positive lesions. We performed histological analysis of atrophy, hyperplasia, and lymphocyte infiltration in these lesions, comparing low PI-RADS lesions and high PI-RADS lesions.
RESULTS
The frequencies of prostate hyperplasia and lymphocyte infiltration were higher in high PI-RADS lesions than in low PI-RADS lesions (p=0.028 and 0.024, respectively). There was no significant difference regarding atrophy (p=0.295).
CONCLUSION
Histopathological change may be one of the reasons for false-positive lesions.
背景/目的：多参数磁共振成像（mpMRI）/超声融合前列腺活检（FB）是一种比传统前列腺活检更准确的诊断方法，但仍存在假阳性病变。有限的研究通过组织学分析检查了假阳性病变的原因。
患者和方法
我们检查了 322 名接受 mpMRI/经直肠超声（TRUS）FB 的患者。我们将前列腺影像报告和数据系统（PI-RADS）3 和 PI-RADS 4-5 分别归类为低 PI-RADS 病变和高 PI-RADS 病变。总共确定了 105 个假阳性病变。我们对这些病变中的萎缩、增生和淋巴细胞浸润进行了组织学分析，并比较了低 PI-RADS 病变和高 PI-RADS 病变。
结果
高 PI-RADS 病变中前列腺增生和淋巴细胞浸润的频率高于低 PI-RADS 病变（p=0.028 和 0.024）。萎缩无显著差异（p=0.295）。
结论
组织病理学变化可能是假阳性病变的原因之一。
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