PI-RADS 4类假阳性病变分析：来自单一非学术中心采用认知融合的经验
Analysis of false positive PI-RADS 4 lesions: experience from a single nonacademic center using cognitive fusion.
作者信息
de Souza Bianca Carla Azevedo, Novaes Marco Antonio Soares, de Souza Maiara Ferreira, do Amaral Maria Estela Pompeu, Mota Augusto, Athanazio Daniel Abensur
机构信息
Federal University of Bahia/Hospital Universitário Professor Edgard Santos, R. Augusto Viana, s/n - Canela, Salvador, 40301-155, Brazil.
Rede D'or Bahia. Av. São Rafael, 2152 - São Marcos, Salvador, BA, 41253-190, Brazil.
出版信息
Int Urol Nephrol. 2023 May;55(5):1081-1085. doi: 10.1007/s11255-023-03508-1. Epub 2023 Feb 18.
BACKGROUND
We evaluated pathological findings in targeted biopsies of PI-RADS4 and PI-RADS5 lesions, and clinical data that could predict those patients with benign findings.
MATERIALS AND METHODS
A retrospective study was conducted to summarize the experience from a single nonacademic center using cognitive fusion and a 1.5 or 3.0 Tesla scanner.
RESULTS
We found a false positive rate of 29 and 3.7% for any cancer in PI-RADS 4 and 5 lesions, respectively. Diverse histologic patterns were observed among target biopsies. At multivariate analysis, size ≤ 6 mm and previous negative biopsy were independent predictors of false positive PI-RADS4 lesions. The small number of false PI-RADS5 lesions precluded further analyses.
CONCLUSION
Benign findings are common in PI-RADS4 lesions and most of them do not show obvious glandular or stromal hypercellularity as expected in hyperplastic nodules. Size ≤ 6 mm and previous negative biopsy predict a higher probability of false positive results in patients with PI-RADS 4 lesions.
背景
我们评估了PI-RADS 4类和5类病变靶向活检的病理结果，以及能够预测活检结果为良性的患者的临床数据。
材料与方法
进行了一项回顾性研究，以总结一个非学术中心使用认知融合和1.5或3.0特斯拉扫描仪的经验。
结果
我们发现PI-RADS 4类和5类病变中任何癌症的假阳性率分别为29%和3.7%。在靶向活检中观察到多种组织学模式。多因素分析显示，直径≤6 mm和既往活检阴性是PI-RADS 4类病变假阳性的独立预测因素。由于PI-RADS 5类病变假阳性数量较少，无法进行进一步分析。
结论
PI-RADS 4类病变中良性结果很常见，其中大多数病变未显示出增生性结节中预期的明显腺体或间质细胞增多。直径≤6 mm和既往活检阴性提示PI-RADS 4类病变患者出现假阳性结果的可能性较高。
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