Kour Pawandeep, Afzal Saima, Gani Adil, Zargar Mohammed Iqbal, Nabi Tak Umar, Rashid Showkat, Dar Aijaz Ahmad
Soft Matter Research Group, Physical Chemistry Section, Department of Chemistry, University of Kashmir, Hazratbal, Srinagar 190006, J&K, India.
Department of Food Science and Technology, University of Kashmir, Hazratbal, Srinagar 190006, J&K, India.
Food Chem. 2021 Dec 23;376:131925. doi: 10.1016/j.foodchem.2021.131925.
Nanoemulsion encapsulated in the hydrogel beads are important entrants for loading hydrophobic active ingredients for enhancing their bioavailability and biological activities relevant in the pharmaceutical, food and cosmetic industries. Herein, we report the formulation of curcumin-loaded nanoemulsion encapsulated in ionotropic hybrid hydrogel beads of alginate, chitosan, gelatin and polyethylene oxide for effective delivery of curcumin. The release behaviour in simulated gastric and intestinal fluids (SGF and SIF) at 37 °C showed faster release in SGF which could be explained on the basis of mesh size, the extent of hydration and the complexation of the curcumin with the Ca ions present within the hydrogel network. The free radical scavenging and antibacterial activities of the released curcumin in SGF were significantly greater than in SIF. This study shows promises of such hybrid systems, ignored so far, for proper encapsulation, protection and delivery of curcumin for the development of functional foods and pharmaceutics. The high structural stability of these nanoemulsion carriers and their effective delivery of curcumin provide a novel and tailored formulation out of existing polymers with plethora of advantages for oral drug delivery. Moreover, this study opens new door for different possibilities to improve the physicochemical characteristics and delivery of bioactive molecules like curcumin.
包裹在水凝胶珠中的纳米乳液是用于负载疏水性活性成分的重要载体，可提高其在制药、食品和化妆品行业中的生物利用度和生物活性。在此，我们报道了一种将负载姜黄素的纳米乳液包裹在藻酸盐、壳聚糖、明胶和聚环氧乙烷的离子型混合水凝胶珠中的制剂，用于姜黄素的有效递送。在37℃下模拟胃液和肠液（SGF和SIF）中的释放行为表明，姜黄素在SGF中的释放速度更快，这可以基于水凝胶网络中的孔径大小、水合程度以及姜黄素与钙离子的络合来解释。在SGF中释放的姜黄素的自由基清除和抗菌活性显著高于在SIF中的活性。这项研究表明，这种迄今为止被忽视的混合系统有望用于姜黄素的适当包封、保护和递送，以开发功能性食品和药物。这些纳米乳液载体的高结构稳定性及其对姜黄素的有效递送提供了一种新型且定制的制剂，该制剂由现有聚合物制成，具有口服药物递送的诸多优势。此外，这项研究为改善姜黄素等生物活性分子的物理化学特性和递送开辟了不同可能性的新途径。
