Department of Plastic Surgery and Burns, Pinderfields Hospital, Mid Yorkshire NHS Trust, UK.
Department of Plastic Surgery and Burns, Pinderfields Hospital, Mid Yorkshire NHS Trust, UK.
Burns. 2022 Nov;48(7):1618-1625. doi: 10.1016/j.burns.2021.12.004. Epub 2021 Dec 21.
The antimicrobial properties of bromelain have been previously studied. However, the effect of enzymatic debridement on bacterial colonisation in burn wounds was not described in literature. In this study, we examine whether bromelain-based enzymatic debridement using NexoBrid® gel alters the microbiological pattern of burn wounds. Bacterial emergences in burn wounds that were enzymatically debrided at Pinderfields Regional Burns Centre, between July 2016 and February 2019, were studied and compared to the bacterial profile of burn wounds that were managed either by surgical debridement or dressings only during the same period. Our results showed that the microbial profile of burn wounds treated with NexoBrid® is similar to what is widely reported in cases treated without enzymatic debridement, at all stages of wound healing. This particularly showed in the predominance of Gram-positive organisms in the first week and Gram-negative in the second week.
菠萝蛋白酶的抗菌特性此前已有研究。然而，文献中并未描述酶清创对烧伤创面细菌定植的影响。在这项研究中，我们研究了使用 NexoBrid®凝胶进行基于菠萝蛋白酶的酶清创是否会改变烧伤创面的微生物模式。研究了 2016 年 7 月至 2019 年 2 月在 Pinderfields 地区烧伤中心进行酶清创的烧伤创面的细菌出现情况，并与同期仅通过手术清创或敷药处理的烧伤创面的细菌情况进行了比较。我们的结果表明，NexoBrid®治疗的烧伤创面的微生物谱与未经酶清创治疗的广泛报道的情况相似，在所有愈合阶段均如此。在第一周以革兰氏阳性菌为主，第二周以革兰氏阴性菌为主，这一点尤为明显。
