二苯乙烯类化合物与 adiporon 作为实验性终末期 2 型糖尿病大鼠脂联素调节剂的比较。
Diacerein versus adipoRon as adiponectin modulators in experimentally-induced end-stage type 2 diabetes mellitus in rats.
机构信息
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.
Department of Basic Medical Sciences, College of Medicine, Almaarefa University, P.O. Box 71666, Riyadh, 11597, Saudi Arabia; Department of Anatomy, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
出版信息
Environ Toxicol Pharmacol. 2022 Feb;90:103806. doi: 10.1016/j.etap.2021.103806. Epub 2021 Dec 31.
The objective of the present study is to evaluate and compare the possible anti-diabetic effects of adipoRon and diacerein in type 2 diabetes mellitus (T2DM) rats. T2DM is marked by impaired oxidative, inflammatory and metabolic signaling. Indeed, T2DM progression is associated with elevated HbA1C%, low adiponectin and insulin concentration. Moreover, in this study epididymal adipose tissue and soleus muscle MDA contents significantly escalated, while serum TAC and epididymal adipose Nrf2 significantly declined. Nevertheless, serum TNF-α, epididymal NLRP3, NF-κB, PPARγ and CD68 expression rose significantly with a parallel significant reduction in serum IL-10 and soleus muscle expression of IRS1. Both adipoRon and diacerein significantly improved adiponectin and insulin secretion with augmentation of anti-oxidant defenses and diminution of oxidative burden, with obvious anti-inflammatory consequences (p < 0.05). Thus, adipoRon and diacerein positively modulated adiponectin expression with down-regulation of NF-κB/NLRP3/PPARγ expression with subsequent improvement in glycemic control, inflammatory and oxidative signaling.
本研究旨在评估和比较 adiporon 和 diacerein 在 2 型糖尿病（T2DM）大鼠中的潜在抗糖尿病作用。T2DM 的特点是氧化、炎症和代谢信号受损。事实上，T2DM 的进展与 HbA1C%升高、脂联素和胰岛素浓度降低有关。此外，在这项研究中，附睾脂肪组织和比目鱼肌 MDA 含量显著升高，而血清 TAC 和附睾脂肪组织 Nrf2 显著下降。然而，血清 TNF-α、附睾 NLRP3、NF-κB、PPARγ 和 CD68 的表达显著升高，同时血清 IL-10 和比目鱼肌 IRS1 的表达显著降低。adipoRon 和 diacerein 均能显著改善脂联素和胰岛素的分泌，增强抗氧化防御，减轻氧化应激，具有明显的抗炎作用（p<0.05）。因此，adipoRon 和 diacerein 可通过下调 NF-κB/NLRP3/PPARγ 的表达来正向调节脂联素的表达，从而改善血糖控制、炎症和氧化信号。
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