二醋酸姜黄素通过降低 2 型糖尿病大鼠的炎症反应和胰岛素抵抗来减轻血管功能障碍。
Diacerein attenuates vascular dysfunction by reducing inflammatory response and insulin resistance in type 2 diabetic rats.
机构信息
Division of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Division of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
出版信息
Biochem Biophys Res Commun. 2021 Dec 31;585:68-74. doi: 10.1016/j.bbrc.2021.11.017. Epub 2021 Nov 10.
AIM
To examine the effect of diacerein on vascular dysfunction in type 2 diabetic rats and elucidate the mechanism of diacerein.
METHODS
In a rat model, type 2 diabetes was induced by high-fat diet and streptozotocin. Vascular function was assessed in vascular reactivity experiment. The effect of diacerein (10 or 20 mg/kg/day) on blood glucose, inflammation and insulin signaling, and modulators in vascular tissue in diabetic rats were investigated by molecular and biochemical approaches.
RESULTS
In this study, diacerein inhibited diabetes-induced vascular dysfunction. Diacerein treatment normalized blood glucose, insulin tolerance test, inflammatory cytokine levels and nitric oxide synthases expression in diabetic rats. Moreover, diacerein inhibited NF-κB and NLRP3 pathways and activated insulin signaling pathway related proteins IRS-1 and AKT in diabetic rats.
CONCLUSION
Diacerein improved vascular function effectively in diabetic rats by suppressing inflammation and reducing insulin resistance. These results suggest that diacerein may represent a novel therapy for patients with diabetes.
目的
研究二乙酰瑞林对 2 型糖尿病大鼠血管功能障碍的影响，并阐明二乙酰瑞林的作用机制。
方法
采用高脂饮食和链脲佐菌素诱导大鼠 2 型糖尿病模型。通过血管反应性实验评估血管功能。采用分子和生化方法研究二乙酰瑞林（10 或 20mg/kg/天）对糖尿病大鼠血糖、炎症和胰岛素信号以及血管组织中调节剂的影响。
结果
本研究表明，二乙酰瑞林抑制了糖尿病引起的血管功能障碍。二乙酰瑞林治疗使糖尿病大鼠的血糖、胰岛素耐量试验、炎性细胞因子水平和一氧化氮合酶表达恢复正常。此外，二乙酰瑞林抑制了 NF-κB 和 NLRP3 途径，并激活了糖尿病大鼠胰岛素信号通路相关蛋白 IRS-1 和 AKT。
结论
二乙酰瑞林通过抑制炎症和减轻胰岛素抵抗，有效地改善了糖尿病大鼠的血管功能。这些结果表明，二乙酰瑞林可能为糖尿病患者提供一种新的治疗方法。
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